🇺🇸 United States Episodes

Sometimes the world's biggest issues can seem so intractable that meaningful change feels impossible. But what if the answer has been right in front of us all along? What if the answer is actually throwing money at the problems? In this thought-provoking talk, philanthropic advisor Natalie Cargill shares what might happen if we came together to spend 3.5 trillion dollars on fixing the world. And, yes, she also has a plan for where to get the money from. (Followed by a Q&A with Anna Verghese, executive director of The Audacious Project.)Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

Episode 495: Shaan Puri (https://twitter.com/ShaanVP) and Sam Parr (https://twitter.com/theSamParr) talk with Kevin Ryan, Founder and CEO of AlleyCorp, an incubator and venture capital fund behind Business Insider, MongoDB, GILT and Zola among others. Kevin shares how he runs his +$20B venture studio AlleyCorp, why Buzzfeed ultimately failed, how he launches 8 companies a year and much more. Want to see more MFM? Subscribe to the MFM YouTube channel here. — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com/ Check Out Shaan's Stuff: • Try Shepherd Out - https://www.supportshepherd.com/ • Shaan's Personal Assistant System - http://shaanpuri.com/remoteassistant • Power Writing Course - https://maven.com/generalist/writing • Small Boy Newsletter - https://smallboy.co/ • Daily Newsletter - https://www.shaanpuri.com/ — Show Notes: (0:00) Intro (3:15) Selling DoubleClick to Google for ~$3B (5:20) Starting Business Insider, MongoDB and Gilt (11:00) What led Kevin to start Business Insider (15:00) Why Kevin hired Henry Blodget to run Business Insider (16:45) What did Buzzfeed get wrong? (18:45) Why has AlleyCorp been such a success compared to other venture studios?   (29:20) What businesses Kevin’s excited about right now (39:00) Thoughts on buy vs. build vs. bootstrap (41:00) What business has been the easiest and most profitable? (42:50) Thoughts on AI (44:50) Launching 8 companies a year (47:40) Why Kevin isn’t on social media (50:20) Starting companies in the recruiting space (54:20) The benefit of being emotionally stable (56:20) Kevin’s investment portfolio — Links: • Kevin’s Linkedin - https://www.linkedin.com/in/kevinryan3/ • AlleyCorp - https://alleycorp.com/ • Business Insider - https://www.businessinsider.com/ • Henry Blodget - https://twitter.com/hblodget • MongoDB - https://www.mongodb.com/ • Gilt - https://www.gilt.com/ • The Ladders - https://www.theladders.com/ • RippleMatch - https://ripplematch.com/ • Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. — Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. — Other episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto • #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

Dr Anna Machin is an evolutionary anthropologist at Oxford University, a researcher into the role of fatherhood across time and an author. The modern world has made dads surplus to requirements in many ways. The deadbeat dad is such a meme in sitcoms and cartoons now that it's no surprise men don't feel they have a role in child rearing. But just how important are fathers to the development of boys and girls? And what don't we know about their impact? Expect to learn how fathers saved the human race when babies heads got too big, whether it's normal for dads to not feel love for their baby when it's born, the most important ways dads can bond with their kids, whether dads are more important to girls' or boys' development, what pushback Anna got for writing a pro-father book and much more... Extra Stuff: Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ Learn more about your ad choices. Visit megaphone.fm/adchoices

In China, data on the economy is sometimes difficult to come by. The Chinese government has put a pause on releasing some of its official economic data. But many of the stories emerging from the country paint a clear picture: the second largest economy in the world is struggling.Today, our friends at The Indicator share some of their recent reporting on China. First up, it's a special edition of the Beigie Awards focused entirely on China. What can the approach of the Federal Reserve's Beige Book - i.e. looking at anecdotes that tell us something about where the economy is headed - show us about China's economy?Then, we take a deep dive into one of the most alarming indicators in China: the skyrocketing urban youth unemployment rate.This episode was hosted by Darian Woods, Wailin Wong, and Robert Smith. The original Indicator episodes were produced by Corey Bridges with engineering by Robert Rodriguez. They were fact-checked by Cooper Katz McKim and Sierra Juarez. They were edited by Paddy Hirsch and Kate Concannon.Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Jeremy Jones is a professional pool player. He was the 1998 US Open One Pocket champion, the 2003 US Open 9 Ball champion, and has represented Team USA in the Mosconi Cup on seven occasions.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Everyone loses their temper from time to time — but the stakes are dizzyingly high when the focus of your fury is your own child. Clinical psychologist and renowned parenting whisperer Becky Kennedy is here to help. Not only does she have practical advice to help parents manage the guilt and shame of their not-so-great moments but she also models the types of conversations you can have to be a better parent. (Hint: this works in all other relationships too.) Bottom line? It's never too late to reconnect.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

with @alive_eth @danboneh @smc90 The convergence of two important, very top-of-mind trends: artificial intelligence & blockchains/ crypto. The conversation covers everything from deep fakes and bots and proof-of-humanity in a world of AI, to big data, LLMs like ChatGPT, user control, governance, privacy and security, zero-knowledge machine learning, MEV, media and generative art, and and much, much more.

This is episode 2 of a 4-part special series on mental health with Dr. Paul Conti, M.D., a Stanford and Harvard-trained psychiatrist currently running a clinical practice, the Pacific Premiere Group. Dr. Conti explains specific tools for how to overcome life’s challenges using a framework of self-inquiry that explores all the key elements of self, including defense mechanisms, behaviors, self-awareness and attention. We also discuss our internal driving forces, how to align them and ultimately, how to cultivate a powerful “generative drive” of positive, aspirational pursuits. Dr. Conti also explains how to adjust your internal narratives, reduce self-limiting concepts, overcome intrusive thoughts, and how certain defense mechanisms, such as “acting out” or narcissism, show up in ourselves and others. The next episode in this special series explores how to build healthy relationships with others. For the full show notes, including articles, books, and other resources, visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Waking Up: https://wakingup.com/huberman Eight Sleep: https://eightsleep.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Improve Mental Health (00:02:19) Sponsors: BetterHelp & Waking Up App (00:05:26) Structure & Function of Healthy Self  (00:16:25) Agency & Gratitude (00:21:14) Aggressive Drive, Pleasure Drive, Generative Drive (00:30:00) Physical & Mental Health Similarities, Verb States (00:37:05) Sponsor: AG1 (00:38:32) Lack of Motivation, Drives (00:43:06) Video Games/Social Media & Distraction, Generative Drive (00:51:46) Asking Better Questions, Psychiatric Medicine, Physical Health Parallels (00:59:10) Sponsor: Eight Sleep (01:00:30) Self-Reflection & Structure of Self “Cupboards”, Trauma & Agency (01:08:53) Feeling Stuck, Defense Mechanisms & Sublimation, Character (01:13:58) Self-Reflection & Function of Self “Cupboards”, Self-Awareness (01:19:24) Defense Mechanisms & “Acting Out” (01:26:43) Salience, Intrusive Thoughts (01:31:24) Self-Reflection, Behaviors & Strivings; Roadmap Forward (01:38:25) Internal Narratives, Childhood (01:44:44) Internal Narratives: Self-Scrutiny & Overcoming; Trauma (01:55:18) Time Required for Change, Understanding Intrusive Thoughts (02:03:13) Self-Reflection on Internal Drives; Envy (02:09:56) Generative Drive; Strong Aggressive Drive & Envy (02:21:50) High Aggressive Drive & Social Relationships, Narcissism (02:28:43) Narcissism, Destruction, Envy (02:37:18) Narcissism & Childhood, Change (02:41:26) Engaging with Narcissists, Disengagement (02:44:47) Demoralization, Learned Helplessness (02:49:34) Self-Inventory of Drives, Optimization (02:56:09) Social Media & Salience, Generative Drive (03:03:21) Rational Aspiration (03:13:16) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Momentous, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices

Original Air Date: November 12th, 2018 Dr. BJ Miller is a hospice and palliative care specialist who treats patients with life-altering and terminal illnesses at the University of California in San Francisco. Dr. Miller shares his revelations about a subject that is often taboo in our culture: the experience of death. He describes the moment after a person's death and explains why it is both sacred and unknowable. While a sophomore in college, Dr. Miller suffered a devastating electrical shock throughout his body. He lost half his arm and both his legs below the knee. He talks about how this earth-shattering experience proved to be a spiritual wake-up call and how it left him with an extraordinary sense of what it means to confront death. Dr. Miller discusses why he thinks it’s time for us to rethink the idea that “death is inherently horrible.” He also reveals what he's learned about regret by experiencing “vicarious deathbed moments” in his practice. Dr. Miller’s book is titled “A Beginner’s Guide to the End.” Want more podcasts from OWN? Visit https://bit.ly/OWNPods You can also watch Oprah’s Super Soul, The Oprah Winfrey Show and more of your favorite OWN shows on your TV! Visit https://bit.ly/find_OWN

Matt Rife is a stand-up comic and actor who has appeared in the television series "Wild 'n Out" and "Brooklyn Nine-Nine," and recorded three comedy specials. His most recent, "Matt Rife:Walking Red Flag," is available to stream on Youtube. www.mattrifeofficial.com Learn more about your ad choices. Visit podcastchoices.com/adchoices

Peter McIndoe isn't a fan of birds. In fact, he has a theory about them that might shock you. Listen along to this eye-opening talk as it takes a turn and makes a larger point about conspiracies, truth and belonging in divisive times.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

Become more comfortable and confident in in-the-moment speaking situations.

It is now accepted wisdom that increasing the diversity of your workforce in any dimension can improve both organizational culture and performance. But one group — people living with intellectual, developmental, and physical disabilities — continues to be overlooked by many companies. Luisa Alemany, associate professor at London Business School, has studied workplaces that do recruit and hire employees with disabilities and found that it can be a true source of competitive advantage. She explains four main ways this talent strategy benefits the firm. She’s the coauthor, along with Freek Vermeulen, of the HBR article “Disability as a Source of Competitive Advantage.”

Episode 495: Shaan Puri (https://twitter.com/ShaanVP) and Sam Parr (https://twitter.com/theSamParr) talk with Derek from More Plates More Dates (https://www.youtube.com/@MorePlatesMoreDates) about his origin story, +$100M business empire, investment portfolio, his thoughts on Bryan Johnson, how he sources his food and much more. Want to see more MFM? Subscribe to the MFM YouTube channel here. — Check Out Shaan's Stuff: • Try Shepherd Out - https://www.supportshepherd.com/ • Shaan's Personal Assistant System - http://shaanpuri.com/remoteassistant • Power Writing Course - https://maven.com/generalist/writing • Small Boy Newsletter - https://smallboy.co/ • Daily Newsletter - https://www.shaanpuri.com/ Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com/ — Show Notes: (0:00) Intro (7:15) Why Pickup artists are often great entrepreneurs (12:50) Derek’s business empire (21:30) Degrees of difficulty with Derek’s businesses (28:00) What are Derek’s business goals? (39:25) Derek’s investment portfolio (43:45) The origin story of More Plates More Dates (52:00) How Derek became a health science expert (54:20) Thoughts on Bryan Johnson (1:00:25) Taking TRT and other supplements (1:06:15) Where Derek buys his food — Links: • More Plates More Dates Youtube - https://www.youtube.com/c/MorePlatesMoreDates • Derek's Twitter - https://twitter.com/Derek_Fitness • Gorilla Mind - https://gorillamind.com/ • Marek Health - https://marekhealth.com/ • Intelligent Elephant - https://intelligent.shop/ • Good Looking Loser - https://www.goodlookingloser.com/ • Chris's Twitter - https://twitter.com/goodlookinglosr • Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. — Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. — Other episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto • #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

For some entrepreneurs, risk is just part of the game. But for the reluctant entrepreneur, whose endeavors come as a response to a need they've identified, risk can feel more like a necessary evil. That’s why you need to learn to harness risk. Stacey Abrams, an entrepreneur and scale leader both in and outside of politics, is a perfect example of how harnessing risk can be key to your success. Outside of politics, she’s started three companies with her business partner, Lara Hodgson. Their new book, Level Up: Rise Above the Hidden Forces Holding Your Business Back, dives into the lessons learned from those experiences. She also founded and scaled two voting rights organizations: the New Georgia Project and Fair Fight Action, as well as the census mobilization effort Fair Count and the Southern Economic Advancement Project.Read Level Up: Rise Above the Hidden Forces Holding Your Business Back, by Stacey Abrams and Lara Hodgson: https://amzn.to/36bw5AyRead a transcript of this episode: https://mastersofscale.comSubscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My guest today is David Senra, the creator and host of Founders Podcast. With an incredible appetite for biographies, David has delved into the lives of over three hundred entrepreneurs, extracting invaluable wisdom that he shares with his audience each week. Throughout the conversation, we discuss David’s love of podcasts, and what can be gained from studying the lives of not just entrepreneurs, but of athletes and film directors alike. I hope you enjoy this conversation with David Senra. Listen to Founders Podcast Join Colossus live in NYC with Patrick O’Shaughnessy and David Senra on Oct. 19. Our first interview with David, Episode 292: Passion & Pain For the full show notes, transcript, and links to mentioned content, check out the episode page here. ----- This episode is brought to you by Tegus. Tegus is the modern research platform for leading investors. Tired of running your own expert calls to get up to speed on a company? Tegus lets you ramp faster and find answers to critical questions more efficiently than any alternative method. The gold standard for research, the Tegus platform delivers unmatched access to timely, qualitative insights through the largest and most differentiated expert call transcript database. With over 60,000 transcripts spanning 22,000 public and private companies, investors can accelerate their fundamental research process by discovering highly differentiated and reliable insights that can’t be found anywhere else in the market. As a listener, drive your next investment thesis forward with Tegus for free at tegus.co/patrick. ----- Invest Like the Best is a property of Colossus, LLC. For more episodes of Invest Like the Best, visit joincolossus.com/episodes.  Past guests include Tobi Lutke, Kevin Systrom, Mike Krieger, John Collison, Kat Cole, Marc Andreessen, Matthew Ball, Bill Gurley, Anu Hariharan, Ben Thompson, and many more. Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here. Follow us on Twitter: @patrick_oshag | @JoinColossus Show Notes (00:02:43) - (First question) - David's journey so far (00:05:13) - Why there are no negative surprises linked to his work (00:07:13) - Being bullish on podcasts (00:13:27) - The importance of storytelling to the entrepreneurial journey  (00:17:43) - The impulse of entrepreneurs who are world-builders  (00:23:03) - The universal trait of successful entrepreneurs  (00:27:43) - What David has learned from filmmakers  (00:31:23) - The dark side of the Type-A personality (00:35:13) - What he has learned from athletes (00:42:27) - The effects of early childhood on success (00:43:48) - Insights gained from conquerors  (00:49:33) - Ranking the importance he places on power, wealth, and fame (00:56:13) - The possibility of episodes on spiritual figures (01:02:17) - How Henry Ford created something bigger than himself (01:05:43) - His thoughts on ‘high agency’ people (01:11:57) - Why David is not afraid to talk about anything publicly (01:16:27) - His favorite line from Game of Thrones

The flexibility to work from anywhere won't necessarily make you love your job, says HR leader Sarah Aviram. Sharing practical wisdom from research conducted while working remotely in 12 different countries, she reveals the real challenges that hybrid work policies can't fix -- and shows how to truly thrive at your job no matter where you get it done.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

Episode 494: Shaan Puri (https://twitter.com/ShaanVP) talks with ex-CEO & co-founder of Twitch, Emmett Shear (https://twitter.com/eshear), about the potential of artificial intelligence, the value of understanding consumer / users needs, his simple framework for problem-solving, the power of seemingly small ideas that can have a huge impact and lessons he’s directly learned from Silicon Valley greats like Paul Graham and Andy Jassey. Want to see more MFM? Subscribe to the MFM YouTube channel here. — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com/ Check Out Shaan's Stuff: • Try Shepherd Out - https://www.supportshepherd.com/ • Shaan's Personal Assistant System - http://shaanpuri.com/remoteassistant • Power Writing Course - https://maven.com/generalist/writing • Small Boy Newsletter - https://smallboy.co/ • Daily Newsletter - https://www.shaanpuri.com/ — Show Notes: (0:00) Intro (4:30) Did you always have an insatiable curiosity? (8:30) How to solve any problem (13:23) The importance of understanding your customers / users needs (22:15) Emmett’s favorite business ideas right now (41:00) Is AI going to kill us all? (56:50) Was Twitch luck or skill? Will Emmett try to build another unicorn? (59:00) Lessons from Paul Graham (1:09:00) What’s the difference between people who are good vs. great? — Links: • Twitch - https://www.twitch.tv • Paul Graham - https://twitter.com/paulg • Patrick Collison - https://twitter.com/patrickc • Andy Jassey - https://twitter.com/ajassy • Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. — Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. — Other episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto • #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity." We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways. First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose. Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Peter Attia, Journal Club (00:03:43) Sponsors: LMNT & Waking Up (00:06:11) Dreams (00:12:36) Article #1, Metformin, Mitochondria, Blood Glucose (00:19:47) Type 2 Diabetes & Causes, Insulin Resistance (00:25:30) Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study (00:36:37) Sponsor: AG1 (00:37:15) TAME Trial; Demographics, Twin Cohort (00:44:27) Metformin & Mortality Rate (00:51:28) Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power (01:02:23) Hazard Ratios, Censoring (01:09:00) Metformin Advantage?, Variables, Interventions Testing Program (01:16:02) Berberine, Acarbose, SGLT2 Inhibitors (01:23:48) Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers (01:32:22) Tool: Reading Journal Articles, 4 Questions, Supplemental Information (01:38:10) Article #2, Belief Effects vs. Placebo Effect (01:45:22) Nicotine Effects (01:51:07) Nicotine Doses & Belief Effects, fMRI Scan (02:00:07) Biological Effects, Dose-Dependent Response & Belief Effects (02:05:14) Biology & Beliefs, Significance, Dopamine Response, Non-Smokers (02:10:57) Dose-Dependence & Beliefs, Side Effects, Nocebo Effect (02:19:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices

Relish this dish, an ep not to squish… espesh hackers, crackers, and phishers. Ladies and gents, it’s our guest Kara Swisher.