🇺🇸 United States Episodes

After decades of research and billions spent in clinical trials, we still have a problem with cancer drug delivery, says biomedical engineer Elizabeth Wayne. Chemotherapy kills cancer -- but it kills the rest of your body, too. Instead of using human design to fight cancer, why not use nature's? In this quick talk, Wayne explains how her lab is creating nanoparticle treatments that bind to immune cells, your body's first responders, to precisely target cancer cells without damaging healthy ones. Hosted on Acast. See acast.com/privacy for more information.

The Greenland ice sheet is massive, mysterious -- and melting. Using advanced technology, scientists are revealing its secrets for the first time, and what they've found is amazing: hidden under the ice sheet is a vast aquifer that holds a Lake Tahoe-sized volume of water from the summer melt. Does this water stay there, or does it find its way out to the ocean and contribute to global sea level rise? Join glaciologist Kristin Poinar for a trip to this frozen, forgotten land to find out. Hosted on Acast. See acast.com/privacy for more information.

This week’s conversation is about artificial intelligence and interplanetary travel. Its about content creation, thinking from first principles, and death progress units. Its about brain machine interfaces and why it is crucial that you be a chef and not a cook.  My guest is Tim Urban, along with his business partner Andrew Finn. Tim is the most entertaining writer I’ve come across in years, who explains complicated and interesting topics to his millions of dedicated readers on the website “Wait, But Why.” As an example, Tim’s last post on Elon Musk’s neurlink venture is 40,000 words long, roughly the length of a short book. It explains almost all of human progress and our potential future using drawings and cartoons. Its impossible to stop reading. While this conversation is wildly entertaining, it is also chock full of metaphors and lessons that will be useful to anyone doing creative work or building a company. I hope this leaves you as energized as it left me. I called this episode Grand Theft Life because that is the name that Tim and Andrew give to their worldview, which I think will change the way you behave, too. Please enjoy my conversation with Tim Urban.   For comprehensive show notes on this episode go to http://investorfieldguide.com/urban For more episodes go to InvestorFieldGuide.com/podcast. To get involved with Project Frontier, head to InvestorFieldGuide.com/frontier. Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub. Follow Patrick on Twitter at @patrick_oshag   Books Referenced Superintelligence: Paths, Dangers, Strategies   Links Referenced The Cook and the Chef: Musk’s Secret Sauce Wait But Why Neuralink and the Brain’s Magical Future Wait But Hi YouTube Channel  Kurzgesagt – In a Nutshell   Show Notes 1:50 – (First question) –  Explaining his concept of planets 1, 2, 3 and 4 and understanding the human colossus 5:46 – Tim’s favorite idea of the human knowledge compounding 7:52 – Die Progress Units (DPU) 9:45 – Different stages of AI and the positives and negatives of each stage 14;04 – What happens when AI gains breadth and general intelligence 16:23 – The idea of a cook vs a chef and how Tim had the chance to interview Elon Musk 17:48 – Why you should reason from first principles instead of reasoning by analogies 25:19 – Why it’s possible to turn a cook into a chef 30:08 – Why being a chef is the safer route in a world with AI and what Tim has changed in himself as to why. 31:22 – Looking at the discovery process             34:39 – Superintelligence: Paths, Dangers, Strategies\ 40:01 – Being the person who creates the metaphor vs being the people who simply using them             43:41 – YouTube Channel  Kurzgesagt – In a Nutshell 44:54 – Most fun that Tim has had researching a topic 46:08 – Musk model for attaining your goals 53:43 – Why not caring what people think is one of the world’s best superpowers, grand theft life 56:50 – Neuralink – what is it and how did Tim come to research it 1:02:38 – Elon Musk’s concerns about AI 1:14:28 – What then if the Neuralink concept works out 1:18:02 – Kindest thing anyone has done for Tim   Learn More For more episodes go to InvestorFieldGuide.com/podcast.  Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub Follow Patrick on twitter at @patrick_oshag

It's never too late to reinvent yourself. Take it from Paul Tasner -- after working continuously for other people for 40 years, he founded his own start-up at age 66, pairing his idea for a business with his experience and passion. And he's not alone. As he shares in this short, funny and inspirational talk, seniors are increasingly indulging their entrepreneurial instincts -- and seeing great success. Hosted on Acast. See acast.com/privacy for more information.

On December 14, 2012, the unthinkable happened when a lone gunman shot and killed 20 children and six adults at Sandy Hook Elementary School in Newtown, Connecticut. One of the lives lost that day belonged to 6-year-old Ben Wheeler. Ben’s parents, Francine and David, share how embracing love, light and even suffering can be a catalyst for transformation.

with Tim O'Reilly and Benedict Evans In this hallway-style podcast conversation, O'Reilly Media founder Tim O'Reilly and a16z partner Benedict Evans discuss how we make sense of the most recent wave of new technologies --- technologies that are perh...

Jeff Bussgang, a venture capitalist who teaches entrepreneurship at Harvard Business School, knows from personal experience and having funded many startups that there’s more than one way into that world. You don’t have to have a technical background. Excellent communication skills and a high emotional IQ are startup skills, too. Bussgang, the author of “Entering StartUpLand,” walks through the process of finding your dream job in a new company.

with Ion Stoica, Peter Levine, and Sonal Chokshi We’ve already talked quite a bit about the Algorithms, Machines, and People lab at U.C. Berkeley (AMPLab) — all about making sense of big data — so what happens when the entire world moves towards art...

We check our phones upwards of 50 times per day -- but when our kids play around with them, we get nervous. Are screens ruining childhood? Not according to children's media expert Sara DeWitt. In a talk that may make you feel a bit less guilty about passing your phone to a bored kid at a restaurant, DeWitt envisions a future where we're excited to see kids interacting with screens and shows us exciting ways new technologies can actually help them grow, connect and learn. Hosted on Acast. See acast.com/privacy for more information.

Bert Kreischer is a stand-up comedian, actor and reality television host. Check out his book “Life of the Party” on Amazon and his podcast “Bertcast" available on Spotify. Learn more about your ad choices. Visit podcastchoices.com/adchoices

We've all heard that robots are going to take our jobs -- but what can we do about it? Innovation expert David Lee says that we should start designing jobs that unlock our hidden talents and passions -- the things we spend our weekends doing -- to keep us relevant in the age of robotics. "Start asking people what problems they're inspired to solve and what talents they want to bring to work," Lee says. "When you invite people to be more, they can amaze us with how much more they can be." Hosted on Acast. See acast.com/privacy for more information.

Oprah calls this interview one of the most powerful in her career. Author, mentor and criminal justice activist Shaka Senghor turned his life around after spending 19 years in prison and solitary confinement for committing second-degree murder. During his incarceration, an unexpected act of forgiveness led to his spiritual redemption. Shaka discusses the challenges of fixing the soul of a broken prison system that doesn’t focus on rehabilitation and reintegration.

Christina P is a stand-up comedian, and hosts also own podcast with her husband, Tom Segura, called “Your Mom’s House” available on Spotify. Her new special "Mother Inferior" is now available on Netflix. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Artist Eric Dyer spent years working at a computer to produce images for the screen. Longing to get his hands back on his work, he began exploring the zoetrope, a popular 19th-century device that was used to create the illusion of motion long before the arrival of film. In this vibrant talk, he showcases his resulting art inventions: spinning sculptures and that evoke beautiful, dreamlike scenes. (Warning: This talk includes flashing images and lights. Those who are photosensitive or have seizures trigged by strobes are advised to avoid.) Hosted on Acast. See acast.com/privacy for more information.

Neuroscientist Greg Gage takes sophisticated equipment used to study the brain out of graduate-level labs and brings them to middle- and high-school classrooms (and, sometimes, to the TED stage.) Prepare to be amazed as he hooks up the Mimosa pudica, a plant whose leaves close when touched, and the Venus flytrap to an EKG to show us how plants use electrical signals to convey information, prompt movement and even count. Hosted on Acast. See acast.com/privacy for more information.

In episodes one and two of Hash Power, we explored blockchain technology and cryptocurrency investing. In this episode, we discuss the current and potential future states of the crypto world. We cover new forms of cooperation, regulation, security and storage, and why blockchains allow systems to evolve at such a rapid pace.  Be sure to listen until the end, where we close with some advice about conducting ourselves in a new world where creativity reigns and repetitive jobs disappear—a trend that may only accelerate thanks to blockchain technology and cryptocurrencies. Hash Power is presented by Fidelity Investments   For comprehensive show notes on this episode go to http://investorfieldguide.com/hashpower For more episodes go to InvestorFieldGuide.com/podcast. To get involved with Project Frontier, head to InvestorFieldGuide.com/frontier. Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub. Follow Patrick on Twitter at @patrick_oshag    Show Notes 0:05 – Intro to episode 3 and what to expect  4:00 - Olaf Carlson-Wee, founder of Polychain, on how the funding and investing in cryptocurrencies could easily get out of hand  5:00 – How people are creating holding companies to fund cryptocurrencies protocols  6:45 – Decentralized Autonomous Organization (DAO) and how they will replace the aforementioned holding companies  8:32 – Could fully decentralized organizations replace other more traditional organizational structures, even outside of crypto currency  9:59 – How can DAO’s impact everyday lives  12:39 – Why your skills and accomplishments will become more important than who you are or where you are from             15:38 – Ready Player One: A Novel  16:09 - Naval Ravikant, CEO of Angellist, on the way humans cooperate and build new entities  17:51 – When people will demand oversight and regulation over crypto currency  20:42 - Peter Van Valkenburg, Director of Research at Coincenter on the current state of regulation  26:06 - Jameson Lopp on security needed to protect your cryptocurrency             26:22 - Glacierprotocol.org  27:51 - Ari Paul, co-founder of Blocktower, on how nail polish is used to protect their crypto wallet  30:03 – Juan Benet explains the Filecoin Protocol  35:52 - Muneeb Ali, co-founder of Blockstack, on how his team is plans to provide basic tools that will allow the broader developer community to build apps that the cryptocurrency population will use.  38:01 - Comparing blockstack to the analogy of creating a city  40:17 – How the blockstack token fits into everything  43:15 – Fred Ehrsam, co-founder of Coinbase, on forking in blockchains  47:52 – Naval Ravikant on how the idea of work will change in the future, and how that change helped to produce the idea of a blockchain in the first place.  49:31 – Why curiosity should govern what you do in life 53:22 - Naval’s framework for making money   Learn More For more episodes go to InvestorFieldGuide.com/podcast.  Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub Follow Patrick on twitter at @patrick_oshag

Eric Weinstein is a mathematician and economist, and he is also the managing director at Thiel Capital. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Chika Ezeanya-Esiobu wants to see Africans unleash their suppressed creative and innovative energies by acknowledging the significance of their indigenous, authentic knowledge. In this powerful talk, she shares examples of untapped, traditional African knowledge in agriculture and policy-making, calling on Africans to make progress by validating and dignifying their reality. Hosted on Acast. See acast.com/privacy for more information.

They call him the Zen Master. Legendary NBA coach Phil Jackson says that when he began coaching the Chicago Bulls, and later the Los Angeles Lakers, he drew upon the Zen philosophy of mindfulness to help build both teams. He used tai chi, yoga and meditation to help his players live in the moment and put their egos in check. Learn why Phil says, “What I put into the lives of others will come back unto its own.”

Today our heroes cover a deal that might have more impact on life in Silicon Valley than AI, wearables and AR/VR combined… Nestle’s acquisition of Blue Bottle Coffee. Will hipster entrepreneurs and the VCs who love/need them continue to line up around the block for their minimalist coffee experience of choice, now that it’s owned by the Nesquik Bunny? Is this the beginning of Blue Bottle pod machines filling the empty counter space left by Juicero’s demise in VC offices throughout South Park? We investigate.Sponsors:Rippling: https://bit.ly/acquiredripplingStatsig: https://bit.ly/acquiredstatsig25Odd Lots: https://bit.ly/acquiredoddlotsServiceNow: https://bit.ly/acquiredsnMore Acquired!Get email updates with hints on next episode and follow-ups from recent episodesJoin the SlackSubscribe to ACQ2Merch Store!© Copyright 2015-2025 ACQ, LLCTopics Covered Include:The rise of “Third Wave” coffeeBlue Bottle founder James Freeman’s “classical” (music) influences Venture capital and the coffee business Achieving liquidity when companies and founders’ don’t want to go public, and don’t want to sell their stakes Nestle’s position in single-serve coffee market and potential brand impact of Blue Bottle The Carve Out: Ben: There Never Was a Real Tulip FeverDavid: iPhone SE