🇺🇸 United States Episodes

In this episode of Huberman Lab Essentials, my guest is Dr. Karl Deisseroth, M.D., Ph.D., a clinical psychiatrist and professor of bioengineering and of psychiatry and behavioral sciences at Stanford University. We discuss his experiences as a clinician treating complex psychiatric conditions and his lab’s pioneering work in developing transformative therapies for mental illness. He explains the complexities of mental illness and how emerging technologies—such as optogenetics and brain-machine interfaces—could revolutionize care. We also explore promising new therapies, including psychedelics and MDMA, for conditions like depression and PTSD. Read the episode show notes at hubermanlab.com. Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch or listen to the full-length episode at ⁠hubermanlab.com⁠. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Karl Deisseroth; Neurology vs Psychiatry 00:01:36 Speech; Blood Test?; Seeking Help 00:04:20 Feelings, Jargon; Psychiatric Treatment 00:09:40 Sponsor: David 00:10:55 Future Treatment; Vagus Nerve Stimulation, Depression, Optogenetics 00:19:40 Brain-Machine Interfaces 00:20:53 Sponsor: Eight Sleep 00:23:00 ADHD Symptoms, Lifestyle, Technology 00:29:34 Psychedelics, Depression Treatment, Risks 00:35:43 Sponsor: AG1 00:37:30 MDMA (Ecstasy), Trauma & Post-Traumatic Stress Disorder (PTSD) Treatment 00:40:33 Projections: A Story of Human Emotions Book, Optimism Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

What can we say about the lovely Tina Fey? The talented actor, writer, creator and producer is granted 1-hour of time from her parole officer / daughter to blast out a quick pod with her GPS ankle-bracelet triangulated by 3 cell towers. It's explosive, it's magical, and it Juliennes fries. This episode was originally released on 5/10/2021.

Martha Beck is a sociologist, life coach, and an author. Why is anxiety so widespread today? It feels like nearly everyone is struggling with it in some form, but where does it come from, and what are the most effective ways to manage it or overcome it completely? Expect to learn why anxiety always lies, what most people misunderstand about how anxiety works, the true tension between anxiety and creativity and the role creativity plays in anxiety expression, how to overcome your negative inner voice, why most people get stuck when undergoing a personal transformation, how to become your trust and most authentic self, how to overcome trauma and resentment and much more… Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get a 20% discount & free shipping on Manscaped’s shavers at https://manscaped.com/modernwisdom (use code MODERNWISDOM20) Get the brand new Whoop 5.0 at https://join.whoop.com/modernwisdom Get the best bloodwork analysis in America at https://functionhealth.com/modernwisdom Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: https://tinyurl.com/43hv6y59 #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: https://tinyurl.com/2rtz7avf #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: https://tinyurl.com/3ccn5vkp - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices

The U.S. exports billions of dollars worth of agricultural products each year — things like soybeans, corn and pork. And over the last month, these exports have been caught up in a trade war. U.S. farmers have been collateral damage in a trade war before. In 2018, President Trump put tariffs on a bunch of Chinese products including flatscreen TVs, medical devices and batteries. But China matched those tariffs with their own retaliatory tariffs. They put tariffs on a lot of U.S. agricultural products they'd been buying, like soybeans, sorghum, and livestock. That choice looked strategic. Hitting these products with tariffs hurt Trump's voter base and might help China in a negotiation. And in some cases, China could find affordable alternative options from other countries.Today on the show: what happened in 2018, how the government prevented some U.S. farms from going bankrupt, and what was lost even after the trade war ended.This episode was produced by Sylvie Douglis and edited by Jess Jiang. It was engineered by Robert Rodriguez and fact-checked by Sierra Juarez. Alex Goldmark is our executive producer. Find more Planet Money: Facebook / Instagram / TikTok / Our weekly Newsletter.Listen free at these links: Apple Podcasts, Spotify, the NPR app or anywhere you get podcasts.Help support Planet Money and hear our bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Billions of health insurance claims are processed every year, and around 19% of them are denied. Very few people appeal, but those that do have a chance at a different outcome. Jessica Mendoza speaks to one family about the insurance denial that threw them into a life-or-death crisis, and WSJ’s Julie Wernau on the system they navigated. Further Listening: - Even Doctors Are Frustrated With Health Insurance  - The Cyberattack That's Roiling Healthcare  Sign up for WSJ’s free What’s News newsletter.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Ed Martin was on his way to cleaning up Washington as the new U.S. Attorney, until Senate Republicans decided he was too sincere and killed his nomination. (00:00) Ed Martin’s Response to the Crazed Leftist Who Spit in His Face (07:21) Why Would Republican Senator Thom Tillis Want to Destroy Martin? (09:33) Tillis’s Mission to Lock Up January 6th Protestors (18:14) The DOJ Is a Much Bigger Mess Than People Realize (35:12) Crime and Homelessness in DC (45:26) DC’s Absurd Gun Control Policy Paid partnerships with: Hillsdale College: Take a free online course today at https://TuckerforHillsdale.com Eight Sleep: Get $350 off the new Pod 5 Ultra at https://EightSleep.com/Tucker iTrust Capital: Get $100 funding bonus at https://www.iTrustCapital.com/Tucker Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Zahi Hawass is an archaeologist, Egyptologist, lecturer, and former Egyptian Minister of Antiquities. See him live during his Grand Lecture Tour across North America as he presents the latest groundbreaking discoveries made in Egypt. To check all 33 dates and locations and to register, visit www.ZahiLectures.com 50% off your first box at https://www.thefarmersdog.com/rogan! This video is sponsored by BetterHelp. Visit BetterHelp.com/JRE Learn more about your ad choices. Visit podcastchoices.com/adchoices

What if solving hunger isn't about growing more food but wasting less of it? Social entrepreneur Jasmine Crowe-Houston has made that idea her mission with Goodr, a platform that reroutes surplus food to people in need. In conversation with journalist and "TED Radio Hour" host Manoush Zomorodi, she shares how a viral moment led to a nationwide effort to fix the food waste problem. Hosted on Acast. See acast.com/privacy for more information.

Episode 707: Sam Parr ( https://x.com/theSamParr ) and Shaan Puri ( https://x.com/ShaanVP ) talk to Ankur Nagpal ( https://x.com/ankurnagpal ) about IRS loopholes that can help you grow your net worth plus Ankur shares 6 business ideas.  See Ankur in person at the OOO SUMMIT on Friday, May 16th - https://lu.ma/2025  — Show Notes: (0:00) Ankur's portfolio experiment (10:46) A case for direct indexing (16:29) Super backdoor roth conversions (20:59) Mega backdoor conversion (23:52) IDEA: Executive Clinic for Aesthetics (32:32) IDEA: Amish Farm Imports (36:18) IDEA: Credit Card Agent (43:01) IDEA: Homeownership app (47:35) IDEA: Padel club (56:31) IDEA: Buying a sports team — Links: • Steal Sam's guide to turn ChatGPT into your Executive Coach: https://clickhubspot.com/dvj • Teachable - https://teachable.com/  • Carry - https://carry.com/  • Frec - https://frec.com/  • Superpower - https://superpower.com/  • Flightfox - https://www.flightfox.com/  • Seats.aero - https://seats.aero/  • Home Depot Workshops - https://www.homedepot.com/c/kids-workshop  • The OOO Summit - https://lu.ma/2025  — Check Out Shaan's Stuff: • Shaan's weekly email - https://www.shaanpuri.com  • Visit https://www.somewhere.com/mfm to hire worldwide talent like Shaan and get $500 off for being an MFM listener. Hire developers, assistants, marketing pros, sales teams and more for 80% less than US equivalents. • Mercury - Need a bank for your company? Go check out Mercury (mercury.com). Shaan uses it for all of his companies! Mercury is a financial technology company, not an FDIC-insured bank. Banking services provided by Choice Financial Group, Column, N.A., and Evolve Bank & Trust, Members FDIC — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com • Hampton Wealth Survey - https://joinhampton.com/wealth • Sam’s List - http://samslist.co/ My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano

American healthcare is in crisis—but what if we could change the system by preventing disease before it starts? In this episode of the a16z Podcast, general partner Vijay Pande sits down with Dr. Eric Topol, founder and director of the Scripps Research Translational Institute and one of the most cited researchers in medicine, to explore the cutting edge of preventive healthcare and longevity science. Drawing from his new book Super Agers: An Evidence-Based Path to Longevity, Topol breaks down why understanding the biology of aging—not reversing it—is the key to preventing the “Big Three” age-related diseases: cancer, cardiovascular disease, and neurodegenerative conditions. The conversation spans AI-powered risk prediction, organ clocks, polygenic risk scores, GLP-1s, and the cultural and economic shifts required to move from a “sick care” system to one rooted in precision prevention and extended healthspan. If you’ve ever wondered how data, personalized medicine, and AI can add seven healthy years to your life—and what it will take to bring those benefits to everyone—this episode is for you.

Original Air Date: December 11, 2017 Born in New York City, Pema Chödrön is one of the first Western women to be fully ordained as a Tibetan Buddhist nun. Pema explains how difficult times can be an opportunity for growth and change if you're willing to embrace the situation and the feelings that come with it. One of the basic Buddhist tenets, Pema says, is that change is constant. "Things are going to keep changing," she says. "If you're invested in security and certainty, then you're not going to feel good a lot of the time."

On Monday, to the surprise of global investors, the U.S. and China agreed to a 90-day trade deal. The deal slashed tariffs between the two countries and sent stocks surging.  Leading the negotiations on the U.S. side was Treasury Secretary Scott Bessent. WSJ’s Brian Schwartz, who covered the talks in Geneva, explains how Bessent became President Trump’s man on trade policy and got China to ‘yes’ on a temporary truce. Jessica Mendoza hosts.   Further Listening: -Made In America? Shoe Companies Already Tried That.  -Taking Stock of the ‘Sell America’ Trade  -China Unleashes A Trade War Arsenal  -Tariff Trade-Off: Jobs vs. Higher Prices  Sign up for WSJ’s free What’s News newsletter . Learn more about your ad choices. Visit megaphone.fm/adchoices

Tom Segura is a stand-up comedian, actor, podcaster, and author. He co-hosts two podcasts: “Your Mom’s House” with his wife, comedian Christina Pazsitzky, and “Two Bears, One Cave” with Bert Kreischer. He is also the author of “I’d Like to Play Alone, Please: Essays.” Watch his comedy series, “Bad Thoughts,” now streaming on Netflix.www.ymhstudios.com https://www.netflix.com/title/81740857 Don’t miss out on all the action - Download the DraftKings app today! Sign-up using dkng.co/rogan or with my promo code ROGAN.  GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/18/25 at 11:59 PM ET. Sponsored by DK. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Gen Z slang is rife with new words like "unalive," "skibidi" and "rizz." Where do these words come from — and how do they get popular so fast? Linguist Adam Aleksic explores how the forces of social media algorithms are reshaping the way people talk and view their very own identities. Hosted on Acast. See acast.com/privacy for more information.

In a period of increasing political and economic uncertainty, government funding cuts, and AI that can outperform humans, many people are rightly worried about how those forces might disrupt their careers. Layoffs loom, and even those in senior leadership might soon experience - or have already endured - a setback they weren't expecting. Whitney Johnson, the CEO of Disruption Advisors, has advice on how to deal with the emotions surrounding those kinds of shocks, tactical steps you can take to get back in the game, and ways to learn from the experience so you're better positioned for the future.

The power of creating the reputation you want to have.Whether you know it or not, you have a brand. What that brand is, says Lorraine Lee, doesn’t happen by accident. “You can either form and create it, or you can let people define it for you.”A teacher, content creator, speaker, and author of Unforgettable Presence: Get Seen, Gain Influence and Catapult Your Career, Lee helps people improve their communication presence and define their personal and professional brands. “Your brand is essentially your reputation,” she says. And while she acknowledges that “it can feel intimidating” to actively steer how we’re perceived, her EPIC framework helps navigate this challenge by examining our Experiences, Personality, Identity, and Community.In this episode of Think Fast, Talk Smart, Lee and host Matt Abrahams explore strategies for showing up memorably in both virtual and in-person settings. From crafting "unique and powerful introductions" to honing your online presence, Lee’s practical advice shows how to communicate your brand in today's digital workplace.Episode Reference Links:Lorraine K. LeeLorraine’s Book:  Unforgettable Presence Ep.6 Quick Thinks: Communicating and Leading VirtuallyEp.7 Quick Thinks: Use This Framework to Speak up in Virtual Meetings  Ep.31 Quick Thinks: How to Shine Online and Excel at Virtual Communication Connect:Premium Signup >>>> Think Fast Talk Smart PremiumEmail Questions & Feedback >>> [email protected] Transcripts >>> Think Fast Talk Smart WebsiteNewsletter Signup + English Language Learning >>> FasterSmarter.ioThink Fast Talk Smart >>> LinkedIn, Instagram, YouTubeMatt Abrahams >>> LinkedInChapters:(00:00) - Introduction (02:19) - Tips for Virtual Presence (03:52) - Public Speaking Insights (06:37) - The Importance of Mentors & Sponsors (07:52) - Personal Branding on Social Media (10:27) - EPIC Career Brand Framework (12:52) - Unique & Powerful Introductions (15:07) - Conversational Threading (16:16) - Avoiding Resting Business Face (19:21) - The Final Three Question (23:22) - Conclusion ********Thank you to our sponsors.  These partnerships support the ongoing production of the podcast, allowing us to bring it to you at no cost. Go to Quince.com/ThinkFast for free shipping on your order and 365-day returns. 

Amid polarization, AI disruption, and eroding trust in institutions, retired four-star general, Stanley McChrystal, argues that what leaders need now more than ever, is character. Head of the business consulting firm McChrystal Group, Gen. McChrystal returns to Rapid Response to discuss his new book on the subject of character. From AI ethics and modern warfare to hot-button issues like Signalgate and transgender service in the military, McChrystal explains why character is the foundation of lasting leadership. Drawing from decades of experience, he urges today’s leaders to start standing up for what matters and “be not afraid”. More details about On Character: Choices that Define a Life here.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My guests today are Rick Ruback and Royce Yudkoff. Rick and Royce are Harvard Business School professors who teach their students how to search for, acquire, and run small business directly after graduation. It has been almost a decade since our first conversation, and unlike many past interviews that have become outdated due to technology or market changes, the core principles they shared about entrepreneurship through acquisition remain remarkably relevant today. They explore fascinating developments in the search-fund ecosystem, including the bifurcation between funded searchers targeting larger companies and self-funded entrepreneurs finding success with smaller businesses. Rick and Royce share their accumulated wisdom on what makes a company worth buying, why the "magic is in the multiples," and how their students consistently achieve impressive returns through patient, value-oriented business acquisition. Please enjoy my conversation with Rick Ruback and Royce Yudkoff. For the full show notes, transcript, and links to mentioned content, check out the episode page⁠ here.⁠ ----- This episode is brought to you by⁠ Ramp⁠. Ramp’s mission is to help companies manage their spend in a way that reduces expenses and frees up time for teams to work on more valuable projects. Go to⁠ Ramp.com/invest⁠ to sign up for free and get a $250 welcome bonus. –  This episode is brought to you by⁠ AlphaSense⁠. AlphaSense has completely transformed the research process with cutting-edge AI technology and a vast collection of top-tier, reliable business content. Invest Like the Best listeners can get a free trial now at⁠ Alpha-Sense.com/Invest⁠ and experience firsthand how AlphaSense and Tegus help you make smarter decisions faster. – This episode is brought to you by⁠ Ridgeline⁠. Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. Head to⁠ ridgelineapps.com⁠ to learn more about the platform. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (⁠https://thepodcastconsultant.com⁠). Show Notes: (00:00:00) Welcome to Invest Like the Best (00:05:23) Changes in the Small Firm Acquisition Space (00:06:52) The Impact of SBA Loans on Acquisition Entrepreneurship (00:08:55) The Evolution of Entrepreneurship Through Acquisition (00:10:09) Risk and Return in the Search Fund Model (00:13:38) The Role of Investors in Funded and Unfunded Searches (00:19:33) Criteria for a Good Acquisition Target (00:28:36) The Growing Popularity of Self-Funded Searches (00:43:21) Challenges and Red Flags in Small Firm Acquisitions (00:49:47) Exploring Margin Expansion and Growth (00:51:02) The Impact of Practical Teaching in Business Education (00:52:12) Keys to a Successful Business Class (00:53:30) The Role of Theory in Practical Business Education (00:55:29) Challenges and Rewards of Teaching Business (00:57:46) Capital Allocation in Small Businesses (01:00:50) Advice for Aspiring Business Searchers (01:03:45) Value Creation and Business Lifecycle (01:08:20) Deciding to Leave Private Equity (01:11:20) The Future of Higher Education in Business (01:16:06) Ongoing Relationships with Former Students (01:18:45) Favorite Business Cases to Teach (01:24:46) Encouraging More People to Pursue Business Ownership

Louis travels to Los Angeles to sit down with Hollywood heavyweight and international adventurer, Sean Penn. Renowned for award-winning roles in films like Milk, I Am Sam and Carlito’s Way, Sean discusses his colourful life and career, including dining with Jack Nicholson and Vladimir Putin in Moscow, his relationship with Ukrainian president Volodymyr Zelenskyy and his notorious run-ins with the paparazzi. Warnings: Strong language.   Links/Attachments:    Fast Times at Ridgemont High (1982)  https://www.youtube.com/watch?v=vzva_I8WPAg     Mystic River (2003)  https://www.youtube.com/watch?v=W7NktJhrRYQ     Milk (2008)  https://www.youtube.com/watch?v=w5D07rmfwG0     Dead Man Walking (1995)  https://www.youtube.com/watch?v=kgvbfLNYumU     Carlito’s Way (1993)  https://www.youtube.com/watch?v=_ZMd4Baswb4    The Apprentice (2024)  https://www.youtube.com/watch?v=0_OeYJXXlw0     Superpower (2023)  https://www.youtube.com/watch?v=X54GUzUUM3w     One Flew Over the Cuckoo’s Nest (1975)  https://www.youtube.com/watch?v=OXrcDonY-B8     TV Show: ‘Euphoria’ (2019 – Present) - HBO  https://www.hbo.com/euphoria     Long Day’s Journey into Night (1962)  https://www.imdb.com/title/tt0056196/     TV Show: ‘Normal People’ (2020) - BBC / Hulu  https://www.youtube.com/watch?v=x1JQuWxt3cE    Shanghai Surprise (1986)  https://www.youtube.com/watch?v=NbW06buYw0Y     Song: ‘Like a Virgin’, Madonna (1984)  https://open.spotify.com/track/1ZPlNanZsJSPK5h9YZZFbZ     Becoming Madonna (2024) - Sky Documentaries   https://www.sky.com/watch/programme/4f309d01-57b4-42b1-92ca-82eef6ec747e     A Complete Unknown (2024)  https://www.youtube.com/watch?v=FdV-Cs5o8mc     Audiobook: ‘Chronicles, Volume I’, Bob Dylan (narrated by Sean Penn) (2004)  https://www.simonandschuster.co.uk/books/Chronicles-Volume-1-(Audio)/Bob-Dylan/9780743501613     TV Show: ‘Game of Thrones’ (2011-2019) - HBO  https://www.hbo.com/game-of-thrones     Sweet and Lowdown (1999)  https://www.youtube.com/watch?v=7w3fokY0kP0     Daddio (2024)  https://www.youtube.com/watch?v=PJrr2amlFyc  One Battle After Another (2025)  https://www.youtube.com/watch?v=Ap-j8e9J5U0     TV Show: ‘Merlin’ (2008-2012) - BBC  https://www.bbc.co.uk/iplayer/episode/b00dq8tn/merlin-series-1-1-the-dragons-call?seriesId=b00mjlxv-structural-1-b00dr74v     I am Sam (2001)  https://www.youtube.com/watch?v=ir6_2EkhzAc    Credits:  Producer: Millie Chu   Assistant Producer: Maisie Williams  Production Manager: Francesca Bassett   Music: Miguel D’Oliveira   Audio Mixer: Tom Guest  Video Mixer: Scott Edwards   Shownotes compiled by Immie Webb  Executive Producer: Arron Fellows       A Mindhouse Production for Spotify   www.mindhouse.co.uk   Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dave Smith on the Douglas Murray debate and how he came to find God. (00:00) Dave Smith Breaks Down His Debate With Douglas Murray (10:11) The Biggest Moment of the Debate (15:30) The Moment Douglas Murray Destroyed His Career (35:54) The Real Reason They Want to Destroy Darryl Cooper (46:51) Sam Harris’s Attacks Against Dave Smith (1:09:00) How Con Inc. Tried to Buy Dave Smith (1:16:16) The “Woke Right” Absurdity Paid partnerships with: Silencer Central: Promo code Tucker10 for 10% off your purchase of banish suppressors at https://www.silencercentral.com  SimpliSafe: Visit https://simplisafe.com/TUCKER to claim 50% off & your first month free! PureTalk: Go to https://PureTalk.com/Tucker to make the switch Learn more about your ad choices. Visit megaphone.fm/adchoices