In this exclusive conversation from a16z’s Bio and Health BUILD Summit, founding partner Ben Horowitz sits down with general partner Jorge Conde. They discuss everything from the inspiration behind Ben’s book The Hard Thing About Hard Things, how the open Internet was secured, the difference between wartime and peacetime CEOs, scaling culture, and understanding how bio & healthcare differs from other forms of technology.

From artificial limbs to memory foam, many inventions have emerged from our quest to understand the cosmos. In this episode we explore cosmic history, space's impact on technology, and the enduring human fascination with space exploration. To take us on this journey is astrophysicist John Mather, a Nobel Prize winner for his work on the COBE satellite and a key figure in the James Webb Space Telescope project. Prepare to be intrigued and left with a sense of wonder about the universe's influence on our world.

With students learning in more places and different ways than we have ever seen, the pace of change in education is dizzying. Can this progress narrow learning gaps exacerbated by COVID-19 or will it fuel divides? How can we make the most of this once-in-a-generation opportunity? Join our panelists from Khan Academy, PrismsVR, and Minecraft Education as we discuss the classroom of the future, and how important technologies including AI, XR, and gaming should play a role in it.

With software becoming more important than ever, hardware is following suit. As the world generates more data, unlocking the full potential of AI means a constant need for faster and more resilient hardware. But how much does this all really cost? In this final segment of our AI hardware series, we tackle that question head on. Be sure to check part 1 and 2, where we explore the emerging architectures and the momentous competition for AI hardware.

With the world constantly generating more data, unlocking the full potential of AI means a constant need for faster and more resilient hardware. In this episode – the second in our three-part series – we explore the challenges for founders trying to build AI companies. We dive into the delta between supply and demand, whether to own or rent, where moats can be found, and even where open source comes into play. Look out for the rest of our series, where we dive into terminology and technology that is the backbone of the AI, how much the cost of compute truly costs!

In 2011, Marc Andreessen said, “software is eating the world.” And in the last year, we’ve seen a new wave of generative AI, with some apps becoming some of the most swiftly adopted software products of all time. So if software is becoming more important than ever, hardware is following suit. In this episode – the first in our three-part series – we explore the terminology and technology that is now the backbone of the AI models taking the world by storm. We’ll explore what GPUs are, how they work, the key players like Nvidia competing for chip dominance, and also… whether Moore’s Law is dead? Look out for the rest of our series, where we dive even deeper; covering supply and demand mechanics, including why we can’t just “print” our way out of a shortage, how founders get access to inventory, whether they should own or rent, where open source plays a role, and of course… how much all of this truly costs!

Despite the ease of product building, sustainable growth has become increasingly challenging as many traditional channels no longer deliver the same results. In these challenging times, we explore the remaining growth opportunities. How can we achieve a balance between efficiency, profitability, and growth? Which channels are still relevant and how can they be effectively mastered in 2023? Join us as we discuss these questions with three seasoned experts who have successfully navigated similar confusing times in the past: Gina Gotthilf, leading Latitud and renowned for her impressive tenure as the VP of Growth at Duolingo; Kieran Flanagan, a long-time SVP of Marketing at HubSpot; and Bryan Kim, Consumer GP at a16z, who held various leadership roles during Snap's hypergrowth phase up to its IPO.

Today’s episode is with Mark Cuban, founder of multiple businesses, owner of the Dallas Mavericks, one of the sharks on Shark Tank, and cofounder of the Mark Cuban Cost Plus Drug Company. He is joined by Vijay Pande, founding partner of a16z Bio + Health. Together, they talk market forces in healthcare, the importance of trust to patients, and Mark’s ideas to tackle the Gordian knot that is American healthcare.

Remote work is a big, divisive topic right now. Some think it’s the future, while others think it was an experiment gone wrong. But it’s also not the only way to attract top talent. And the equation for doing so has only gotten more confusion as a myriad of trends intersect, from layoffs to emerging technologies like AI. So how can companies navigate this storm and truly attract the talent that matters? Listen in to find out.

Self-driving cars have been on the horizon for quite some time… But they might actually be here. We got to ride around in one all over San Francisco with Waymo’s Chief Product Officer. We discussed so much, including the five levels of autonomy, the infamous LIDAR vs video debate, regulation, UX, and the role of AI in fine-tuning these models. But most importantly, if autonomy is here… now what?!

A deep dive and tour through key business concepts -- from competitive advantage and Porter's Five Forces, to network effects and moats -- as builders of all kinds navigate business strategy in open source, and especially web3. How does one compete when you're building (and competing) in the open?

This week, a16z’s own cofounder Marc Andreessen published a nearly 7,000-word article that aimed to dispel fears over AI's risks to our humanity – both real and imagined. Instead, Marc elaborates on how AI can "make everything we care about better." In this timely one-on-one conversation with a16z General Partner Martin Casado, Marc discusses how this technology will maximize human potential, why the future of AI should be decided by the free market, and most importantly, why AI won’t destroy the world. In fact, it may save it. Read Marc’s full article “Why AI Will Save the World” here: https://a16z.com/2023/06/06/ai-will-save-the-world/

The holy grail of company building is finding product-market fit. But what most people don’t tell you is that once you’ve found it, product-market fit brings its own set of challenges, particularly when it comes to scaling rapidly and hiring the right executives at the right time. Drawing from their extensive experiences, a16z cofounder Ben Horowitz and Databricks cofounder and CEO Ali Ghodsi sit down to talk about the hardest things about executive hiring and firing, and what is at stake. They dive into the common reasons an exec fails, why sometimes micromanagement is a good idea, and the difference between someone who has written a playbook and someone who has only run one.

Demand for electric cars is booming. More than 10 million electric cars were sold worldwide in 2022, and consumer behavior is changing as more people embrace alternative and sustainable modes of mobility. While the electrification movement is a critical element of climate action, it also presents new challenges - from the sky to the sea. In this episode, industry experts Gregory Davis, CEO of Eviation Planes, Mitch Lee, co-founder and CEO of Arc Boats, and Duncan McIntyre, founder and CEO of Highland Electric Fleets, dive into how the electrification movement is shaping the future of transport and technology.

Today’s episode is with Magi Richani, founder and CEO of Nobell Foods. She is joined by a16z Bio + Health general partner Vijay Pande. Together, they talk about the details of engineering plants to create the future of food, why Nobell started with soybeans to produce their cheese, and her dream of finding a cheese pizza—with Nobell cheese—at any pizza shop across the country.

Many companies today are grappling with a few things: an economic downturn, potential layoffs and restructuring, and trying to keep up with the latest tech trends… all while still maintaining a growth trajectory. In this episode, you’ll learn which companies are uniquely designed to weather this storm and what attributes these exponential organizations have. We’re joined by the co-authors of Exponential Organzations, Peter Diamandids and Salim Ismail, both also well-known for their involvement in XPrize and Singularity University, among many other companies.

In this episode, you’ll hear directly from 6 founders trying to reinvent the healthcare system with the help of Fintech. They’re tackling everything from the lack of price transparency, the complexity of billing, getting clinics paid on time, mental health support for the masses, virtual first-care, and the millions of Americans about to lose access to Medicaid.

2022 was a breakout year for AI. While machine learning had already been integrated into applications for millions of users, for many, these tools still felt like their first real-world encounter with AI. As AI continues to revolutionize industries, CEOs are discussing how to integrate this new superpower. They are also considering important questions around data privacy, competition, cost, accuracy, and speed. In today's episode, we talk with Cresta, Hex, and Sourcegraph, three companies at the forefront of integrating AI into their existing products. From navigating data privacy concerns to optimizing accuracy and managing costs, these CEOs are navigating the complexities of this new superpower.

Most people don’t need a reminder of the state of healthcare in America. But it’s not just the consumer that’s hurting. Medical debt is increasing, billions are lost in unpaid claims, hospitals are in the red, service prices can range up to 30x…. In this episode, a16z GPs Julie You and David Haber explain where the healthcare system breaks down and how the three party system — between payors, providers, and consumers — can be rethought through the lens of Fintech. Learn more about Healthcare x Fintech here: https://a16z.com/healthcare-meets-fintech/

Nvidia’s CEO Jensen Huang declared in a recent keynote, “we are in the iPhone moment of AI.” This special episode will give you an inside look into a16z’s Data and AI Forum, hosted the day GPT-4 came out, featuring many of the most influential builders in the space – from the companies building foundational models like OpenAI to those building the underlying infrastructure like AWS.