Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

From 🇺🇸 Huberman Lab, published at 2025-07-21 08:00

Audio: Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

The Real Deal on Kratom

  1. The Main Idea in a Nutshell

    • Kratom is a complicated plant from Southeast Asia that can act like a coffee-like stimulant at low doses but like a risky, addictive opioid at high doses, and the products sold in the U.S. are often way more powerful and dangerous than the traditional leaf.
  2. The Key Takeaways

    • Two-Faced Effects: At low doses, kratom can give you energy and focus, but at high doses, it can make you feel euphoric and sleepy, similar to an opioid drug.
    • Not All Kratom is Equal: There's a huge difference between the traditional way of chewing fresh kratom leaves and drinking the super-concentrated liquid "shots" and extracts sold in stores today, which are much more potent and hit your body way faster.
    • Three Types of Users: People generally use kratom for one of three reasons: for a daily energy and mood boost (like coffee), to get a sedative, euphoric high, or to help them get off of dangerous opioid addictions.
    • It's Definitely Addictive: The expert makes it clear that with regular use, kratom "absolutely causes a physical dependence," and quitting can feel like caffeine withdrawal for light users or be as bad as opioid withdrawal for heavy users.

    Fun Facts & Key Numbers:

    • Fact: It's estimated that over 20 million people in the U.S. use kratom every single day.
    • Fact: A single small bottle of a kratom extract can contain up to 15 servings, but many people drink the whole thing at once without realizing it.
    • Fact: The kratom plant isn't just one chemical; it contains at least 20 to 40 different active compounds called alkaloids.
  3. Important Quotes, Explained

  • Quote: "> I like to equate it to the the alcohol world where we talk about seltzers or light beers being... more comparable... to that traditional use of kratom, whereas we get to things like... everclear, 190 proof, 95% alcohol. Now you're talking about these isolate products."

    • What it Means: The expert is saying that thinking all "kratom" is the same is like thinking a light beer and a shot of pure alcohol are the same thing. Chewing the leaf is like sipping a light beer, but drinking a concentrated kratom extract is like downing a shot of the strongest possible liquor.
    • Why it Matters: This is a huge deal because stores sell these super-strong kratom products right next to normal energy drinks, but they are worlds apart in terms of risk and power. It highlights how confusing and dangerous the market can be.
  • Quote: "> It does it absolutely causes a physical dependence... if you're utilizing it over a course of time... the physical dependence feeling, um, that most people will report is very similar to that... caffeine withdrawal... [but for others] they get more restless leg syndrome, they get more severe type physical dependence signs, which restless leg is much more related to a opioid withdrawal type issue."

    • What it Means: If you use kratom regularly, your body will get used to it and need it to feel normal. For some, stopping feels like a bad headache from quitting coffee. But for others, especially those using strong products, quitting can cause severe symptoms like restless leg syndrome, which is a classic sign of opioid withdrawal.
    • Why it Matters: This quote directly busts the myth that kratom is a harmless natural supplement. It confirms that it can be seriously addictive, and the withdrawal can range from annoying to awful, depending on what kind and how much you use.
  1. The Main Arguments (The 'Why')

    1. First, the expert argues that you can't just call kratom "good" or "bad" because its effects totally depend on the dose. It has a paradoxical effect: a little bit wakes you up, but a lot knocks you down.
    2. Next, he provides evidence that the kratom products sold in the West are fundamentally different from the plant used traditionally. Modern products are dried, processed, and concentrated, which makes the active chemicals hit your brain much faster and harder, increasing the risk of addiction and harm.
    3. Finally, he points out that because all these different products—from mild powders to super-strong extracts—are just dumped into one big category called "kratom," people have no idea what they're actually taking, which is a major public health problem.
  2. Questions to Make You Think

    • Q: Is the kratom sold in a gas station the same as what people use traditionally in Asia?
    • A: The podcast says no, not at all. Traditional use is chewing fresh leaves or making a weak tea. The stuff in stores is usually a highly concentrated liquid extract made from dried leaves, which is much stronger and is absorbed by your body way faster.

    • Q: Is it true that some famous sodas used to be medicine?

    • A: Yes! The expert mentions that popular soft drinks like Coca-Cola, Pepsi, and 7-Up were originally invented as "pharmacologic tools," or medicines. For example, 7-Up originally had lithium in it to "lift" your mood, and Coca-Cola was made with extracts from the coca leaf.

    • Q: Can kratom actually help people who are addicted to opioids like heroin?

    • A: The text says yes, it has been shown to be effective for this. Some people use kratom to manage the terrible withdrawal symptoms from opioids, and it helps them get their lives back. However, the podcast also warns that this is a specific use case and doesn't mean kratom is safe for everyone, especially young people.
  3. Why This Matters & What's Next

    • Why You Should Care: Kratom products are sold everywhere now, often in gas stations and smoke shops with cool packaging that makes them look like any other energy drink. Because your brain is still developing, it's extra important to know that these products can be very strong, addictive, and risky, even if they're sold legally.
    • Learn More: The podcast mentions how Coca-Cola used to contain drug-like ingredients. To see just how wild the history of our most famous soda is, check out the YouTube video "The Pharmacological History of Coca-Cola" by the channel Brew. It's a fascinating look at how common products can have very surprising origins.

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