🇺🇸 United States Episodes

(0:00) Introducing Eli Lilly CEO Dave Ricks (1:43) How Eli Lilly discovered the GLP-1 impact on weight loss, counterfeit products from China (7:08) GLP-1 pricing and capital allocation after a breakout pharma product (12:56) Why Biotech VC has plummeted, "patent hacking" in China (15:32) Dave's health regimen: good sleep, movement, healthy diet, social relationships, reading (18:32) Unexpected impacts of GLP-1s, helping with addictions, potential mental health use cases (21:16) Thoughts on RFK Jr, Big Pharma's influence on the media, how AI empowers patients (25:27) Impact of proposed NIH cuts, explaining the "PBM boogeyman", next major pharma breakthrough Thanks to our partners for making this happen! Solana - Solana is the high performance network powering internet capital markets, payments, and crypto applications. Connect with investors, crypto founders, and entrepreneurs at Solana's global flagship event during Abu Dhabi Finance Week & F1: https://solana.com/breakpoint OKX - The new way to build your crypto portfolio and use it in daily life. We call it the new money app. https://www.okx.com/ Google Cloud - The next generation of unicorns is building on Google Cloud's industry-leading, fully integrated AI stack: infrastructure, platform, models, agents, and data. https://cloud.google.com/ IREN - IREN AI Cloud, powered by NVIDIA GPUs, provides the scale, performance, and reliability to accelerate your AI journey. https://iren.com/ Oracle - Step into the future of enterprise productivity at Oracle AI Experience Live. https://www.oracle.com/artificial-intelligence/data-ai-events/ Circle - The America-based company behind USDC — a fully-reserved, enterprise-grade stablecoin at the core of the emerging internet financial system. https://www.circle.com/ BVNK - Building stablecoin-powered financial infrastructure that helps businesses send, store, and spend value instantly, anywhere in the world. https://www.bvnk.com/ Polymarket: https://www.polymarket.com/ Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg

Stories of people who try simple mind games on others, and then find themselves way in over their heads. Visit thisamericanlife.org/lifepartners to sign up for our premium subscription.Prologue: Host Ira Glass interviews Lori Gottlieb about the time she sent a letter to a writer in a magazine, a letter packed with white lies. (5 minutes)Act One: Lori Gottlieb's story continues. One complication led to another, and before long, the writer seemed to be lying to her. Or maybe he wasn't. It was hard to tell. Years later, she still isn't sure what happened. (8 minutes)Act Two: A group called Improv Everywhere decides that an unknown band, Ghosts of Pasha, playing their first ever tour in New York, ought to think they're a smash hit. So they study the band's music and then crowd the performance, pretending to be hard-core fans. Improv Everywhere just wants to make the band happy—to give them the best day of their lives. But the band doesn't see it that way. Nor does another subject of one of Improv Everywhere's "missions." (31 minutes)Act Three: Scott Carrier and his family live in the same Salt Lake City neighborhood as Elizabeth Smart, the fourteen-year-old whose 2002 kidnapping made international news. Though Smart's picture was plastered everywhere throughout Salt Lake City and thousands of volunteers searched for her, her captors brazenly brought her back to the very neighborhood from which she'd been taken. They walked freely through the streets with her in broad daylight, yet no one recognized her. Scott talks with his neighbors and his son Milo—who had attended grade school with Smart—about what was going through their minds that prevented them from seeing what was right there in plain sight. (12 minutes)Transcripts are available at thisamericanlife.orgThis American Life privacy policy.Learn more about sponsor message choices.

On Super Bowl Sunday, Jennifer Foley opened a police file and discovered 90 recorded phone calls from her brother’s killer. To Jennifer, what she heard completely undermined Weldon Boyd’s self-defense claims. But the calls also revealed that Boyd had a powerful friend. WSJ’s Valerie Bauerlein reports. Read the Reporting: Nobody Suspected Police Shielded a Killer Until the Dead Man’s Sister Dug In Follow the Story: Camp Swamp Road Playlist Learn more about your ad choices. Visit megaphone.fm/adchoices

I’m excited to share episode one of a new podcast that I’ve helped create and produce. This new podcast is called David Senra, and it’s hosted by David Senra. For those of you not familiar with David Senra, he is an expert in all things related to greatness. He studies greatness and understands it, mostly in the domain of business but also among creatives, athletes and other world-class performers. This first episode of the podcast is with Daniel Ek, the co-founder and CEO of Spotify. It's an absolutely spectacular conversation that I'm certain you'll enjoy. With episode one of David Senra now available, please be sure to subscribe wherever you’re listening so you don't miss future episodes. You can also subscribe to the podcast on the platforms below. Spotify: https://spti.fi/TVrr557 Apple Podcasts: https://apple.co/3WaK1S6 YouTube: https://www.youtube.com/@davidsenra X: https://x.com/davidsenra Chapters (0:00) Introduction from Dr. Andrew Huberman (1:13) Reflecting on a Life-Changing Conversation (2:30) Optimizing for Impact Over Happiness (5:21) The Journey of Self-Motivation (10:11) The Importance of Trust and Relationships (15:37) The Role of Criticism and Self-Reflection (17:37) The Evolution of an Entrepreneur (23:27) Building a Company True to Yourself (34:56) The Power of Trust in Business (42:25) Intellectual Humility and Learning from Others (42:49) Shadowing Leaders for Growth (45:01) Learning from Mark Zuckerberg (48:15) Balancing Personal Taste and Metrics in Product Decisions (53:35) The Evolution of Leadership at Spotify (59:13) Building a Company That Outlasts the Founder (1:15:25) Managing Energy Over Time (1:25:31) The Never-Ending Game of Life (1:25:54) Lessons from Henry Ford (1:27:08) The Value of Solving Problems (1:31:42) The Importance of Quality (1:37:20) The Power of Focus and Patience (1:54:32) Balancing Work and Life (2:00:25) The Journey of Self-Discovery (2:08:43) Final Reflections and Gratitude Learn more about your ad choices. Visit megaphone.fm/adchoices

Note: this talk contains mature content.Shaka Senghor is a resilience expert and New York Times best-selling author, who spent 19 years in prison–including 7 in solitary confinement–for a crime committed when he was young, before finding his path to freedom. In this TED Talks Daily Book Club interview, Elise Hu speaks with Shaka about newest book, How to Be Free: A Proven Guide to Escaping Life’s Hidden Prisons. Elise and Shaka discuss the lessons he learned while incarcerated, and why he believes that these can offer a blueprint to anyone struggling to break free from the hidden prisons in their life. They discuss the important mentors in his life, as well as the crucial role that reading and writing played in helping him “get free.” He also talks about his work with people incarcerated and recently released from prison, and shares why his work and mission always emphasizes the importance of vulnerability and forgiveness, and what it really means to yield to joy.Support Shaka's message! Donate copies of HOW TO BE FREE to young people, incarcerated individuals, and others who need Shaka's message but lack access. Click here! Hosted on Acast. See acast.com/privacy for more information.

Además: ¿mentimos inconscientemente sobre nuestras principales influencias? Este episodio se emitió originalmente el 28 de febrero de 2021.

Success in your career looks different for everyone — but no matter your industry, you'll need to take risks. Company and community builder Molly Graham shares three key skills to learn before jumping off the metaphorical cliff, outlining a path off the corporate ladder and into true professional and personal growth. This episode originally aired on December 3, 2024. Hosted on Acast. See acast.com/privacy for more information.

Announcing our new show, Monitoring the Situation, hosted by a16z General Partners Erik Torenberg and Katherine Boyle, with guest Eddie Lazzarin, CTO of a16z crypto. In this first episode, we ask how American Dynamism, consumer, games, and crypto all fit together, from Palmer/Oculus to Marc Andreessen’s Techno-Optimist Manifesto, while also exploring crypto × AD values, parenting in the AI era, and how internet subcultures shape the news.

In this episode of Pioneers of AI, Jeffrey Katzenberg and ChenLi Wang of the venture capital firm WndrCo share why storytelling is essential for building transformative companies and how AI shapes their work. Learn more about Pioneers of AI: http://pioneersof.ai/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

To celebrate 999, almost 1000, episodes of Modern Wisdom, I broke down some of my favourite lessons, insights and quotes from the last hundred episodes. Expect to learn how 999 episodes of Modern Wisdom have reshaped my understanding of happiness, success and relationships, what i've learned on losing points from Naval Ravikant & Roger Federer, the best isnights on self-belief from Vincent van Gogh, what Viktor Frankl’s paradox of meaning versus pleasure means to me, the biggest insights I've gained over 7 years and 1 billion plays, why lowering your threshold for joy makes you stronger, how busyness can act as an emotional gastric band, the paradox men face between ambition and self-acceptance, how our culture rewires romantic attraction around emotional unavailability, and much more... Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get 15% off your first order of Intake’s magnetic nasal strips at https://intakebreathing.com/modernwisdom Get 15% off any Saily data plan at https://saily.com/modernwisdom Sign up for a one-dollar-per-month trial period from Shopify at https://shopify.com/modernwisdom Timestamps: (0:00) Ringing in 999 Videos (4:39) Why We Need to Take Pleasure in the Small Things (11:08) Productivity is the Same as Gastric Band Surgery (20:59) Every Man Needs Love to Thrive (31:16) How Can We Find Balance in Meaning and Pleasure? (39:22) Uncertainty is a Roadblock to Happiness (46:22) Is Modern Romance Culture Pushing Woman to Pick Emotionally Unavailable Men? (01:03:25) Is Declining Birth Rate the Newest Cassandra Complex? (01:18:42) 7 Lessons About Worrying and Overthinking (01:29:07) How Can We Slow Down Time? (01:38:24) We Need to Escape Our Old Self to Embrace Our New One (01:45:27) Errors in Hesitation are Equal to Errors in Action (01:50:41) Onwards and Upwards Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: https://tinyurl.com/43hv6y59 #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: https://tinyurl.com/2rtz7avf #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: https://tinyurl.com/3ccn5vkp - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices

(0:00) Bestie intros! (2:23) H-1B overhaul: origins and exploitation (25:26) Autism linked to Tylenol usage during pregnancy (43:42) Jimmy Kimmel returns to ABC: comments and reactions (59:21) Two major AI papers (1:09:00) YouTube update (1:12:53) Alphabet admits to COVID censorship under Biden, new CA online hate speech law Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://polymarket.com/event/will-courts-block-trumps-100k-h1b-by-september-30 https://www.cnbc.com/2015/08/18/trump-sort-of-right-on-silicon-valley-visas-calacanis.html https://x.com/RobertMSterling/status/1873174358535110953 https://www.firstpost.com/explainers/deepseek-employees-travel-ban-china-13872040.html https://www.axios.com/2019/12/29/trump-att-outsourcing-h1b-visa-foreign-workers https://hub.jhu.edu/2019/11/05/acetaminophen-pregnancy-autism-adhd/ https://x.com/ThaaatColin/status/1958690862185230539 https://x.com/ThaaatColin/status/1958690862185230539 https://polymarket.com/event/jimmy-kimmel-out-by-september-30?tid=1758935046582 https://x.com/sahilkapur/status/1970211641124847711 https://x.com/shawn_farash/status/1971289990283002022 https://x.com/Scott_Wiener/status/1970307297999007773 https://x.com/thackerpd/status/1971246303243010172 https://support.google.com/youtube/answer/7354993?hl=en https://judiciary.house.gov/media/press-releases/google-admits-censorship-under-biden-promises-end-bans-youtube-accounts https://arxiv.org/pdf/2509.13351 https://www.nature.com/articles/s43588-025-00854-1#Abs1

The next time you open your fridge, take a second to behold the miracles inside of it: Raspberries from California, butter from New Zealand, steak from Nebraska. None of that would have been remotely possible before the creation of the cold chain. The cold chain is the name for the end-to-end refrigeration of our food from farm to truck to warehouse to grocery store and ultimately to our fridges at home. And it’s one of the great achievements of the modern world. On today’s show, Nicola Twilley, food journalist and author of Frostbite: How Refrigeration Changed Our Food, Our Planet, and Ourselves, tells us the story of how our world got cold, and what that’s meant for the economy.  We’ll hear about two pioneers of cold: The cheapskate meat baron Gustavus Swift, and the train-hopping chemist Polly Pennington. And we’ll take a look at whether all this refrigeration might have created some new problems. Subscribe to Planet Money+Listen free: Apple Podcasts, Spotify, the NPR app or anywhere you get podcasts.Facebook / Instagram / TikTok / Our weekly Newsletter.Today’s episode of Planet Money was hosted by Nick Fountain and Alexi Horowitz-Ghazi. It was produced by James Sneed and edited by Keith Romer. It was fact-checked by Sierra Juarez and engineered by Valentina Rodríguez Sánchez. Alex Goldmark is Planet Money's executive producer.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

From the forests of Tanzania to the halls of power, Jane Goodall has spent her life fighting to protect wildlife. But as the planet warms and some governments retreat from environmentalism, is her mission slipping out of reach? Ryan Knutson interviews the renowned conservationist. Further Listening The Head of the EPA on the Future of the Agency How the U.S. Fell Behind China on Climate Diplomacy Sign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Charlie Sheen on tiger blood, sobriety and the lies of 9-11. (0:00) The Infamous “Tiger Blood” Interview (11:20) The Time Sheen Got Booed off Stage in Detroit (29:49) Why Sheen Refused to go to Rehab (35:44) The Key to Getting Sober (59:39) Sheen’s Thoughts on God (1:23:42) Why People Are Scared of the Truth Charlie Sheen is an actor best known for his leading roles in films such as "Platoon," "Wall Street," "Major League," and "Rooftop Killer," and television shows including "Spin City" (for which he won a Golden Globe Award) and "Two and a Half Men." His new book, "The Book of Sheen," is available now. He is featured in the Netflix documentary, "AKA Charlie Sheen," streaming now. Charlie has recently co-founded a new non-alcoholic beer brand called Wild AF, which will be available in October. Born Carlos Estevez, Sheen lives in Malibu, CA, where he grew up. www.charliesheenbook.com www.netflix.com/title/82024990 www.wildafbrewing.com Paid partnerships with: Black Rifle Coffee: Promo code "Tucker" for 30% off at https://www.blackriflecoffee.com Dutch: Get $50 a year for vet care with Tucker50 at https://dutch.com/tucker Eight Sleep: Get $350 off the new Pod 5 Ultra at https://EightSleep.com/Tucker MeriwetherFarms: Visit https://MeriwetherFarms.com/Tucker and use code TUCKER10 for an extra 10% off. Learn more about your ad choices. Visit megaphone.fm/adchoices

Rick Strassman, MD, is a Clinical Associate Professor of Psychiatry at the University of New Mexico School of Medicine. He is the author of several books, the most recent of which is 2024's "My Altered States: A Doctor's Extraordinary Account of Trauma, Psychedelics, and Spiritual Growth."www.rickstrassman.com Buy 1 Get 1 Free Trucker Hat with code ROGAN at https://happydad.com Visit https://WildPastures.com/rogan today to get 20% off for life, plus $15 off your first box. Learn more about your ad choices. Visit podcastchoices.com/adchoices

How do you hold on to hope while still being realistic about the work that needs to be done? Immunology researcher David Fajgenbaum and public health expert Celina de Sola discuss how they scaled personal missions into organizations making long-term impact on communities near and far. They explore how to stay motivated, discover your leadership style and uncover overlooked solutions hiding in plain sight. (This conversation is part of "TED Intersections," a series featuring thought-provoking conversations between experts navigating the ideas shaping our world.) Hosted on Acast. See acast.com/privacy for more information.

Welcome to this classic episode. Classics are my favorite episodes from the past 10 years, published once a month. These are N of 1 conversations with N of 1 people. This Business Breakdowns on Rolex is a long-time stand out. The founder and executive chairman of Hodinkee, Ben Clymer, was the perfect person to take us through the ins and outs of this legendary brand. For the full show notes, transcript, and links to the best content to learn more, check out the episode page ⁠here⁠. ----- This episode is brought to you by ⁠⁠⁠⁠⁠⁠WorkOS⁠⁠⁠⁠⁠⁠. WorkOS is a developer platform that enables SaaS companies to quickly add enterprise features to their applications. With a single API, developers can implement essential enterprise capabilities that typically require months of engineering work. By handling the complex infrastructure of enterprise features, WorkOS allows developers to focus on their core product while meeting the security and compliance requirements of Fortune 500 companies. Visit ⁠⁠⁠⁠⁠⁠WorkOS. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit⁠ joincolossus.com/episodes⁠. Editing and post-production work for this episode was provided by The Podcast Consultant (⁠https://thepodcastconsultant.com⁠). Show Notes (00:00:00) Welcome to Business Breakdowns (00:03:01) His favorite Rolex watch ever (00:04:24) What makes the Rolex Daytona such a special watch  (00:07:19) The job-to-be-done for high-end watches beyond just telling them the time (00:12:18) The strategy behind marketing luxury products: ⁠The Luxury Strategy⁠ (00:14:34) An overview of the Rolex business (00:19:38) The history of Rolex  (00:38:45) Their genius in marketing and distribution  (00:41:55) How they make decisions and what others can learn from them (00:47:14) The financials of Rolex and other luxury watch brands (00:49:02) Most important business lessons others can learn from Rolex (00:52:54) Other luxury brands worth studying  (00:57:26) Negative lessons gleaned from Rolex

Want to start your own business with less than $1k? Get the playbook here: https://clickhubspot.com/fhe Episode 750: Sam Parr ( https://x.com/theSamParr ) and Shaan Puri ( https://x.com/ShaanVP ) talk about the wild rise of Savannah Bananas. — Show Notes: (0:00) The wild story of Savannah Bananas (20:59) How to be insanely great — Links: • The Savannah Bananas - https://thesavannahbananas.com/ • Jesse Cole on Acquired - https://www.acquired.fm/episodes/building-the-savannah-bananas • Monster Jam - https://www.monsterjam.com/ — Check Out Shaan's Stuff: • Shaan's weekly email - https://www.shaanpuri.com • Visit https://www.somewhere.com/mfm to hire worldwide talent like Shaan and get $500 off for being an MFM listener. Hire developers, assistants, marketing pros, sales teams and more for 80% less than US equivalents. • Mercury - Need a bank for your company? Go check out Mercury (mercury.com). Shaan uses it for all of his companies! Mercury is a financial technology company, not an FDIC-insured bank. Banking services provided by Choice Financial Group, Column, N.A., and Evolve Bank & Trust, Members FDIC — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com • Hampton Wealth Survey - https://joinhampton.com/wealth • Sam’s List - http://samslist.co/ My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano

“You now have the leaders of the biggest technology companies in the world saying, effectively in unison, that they do not care how much it costs to build all the way to A.G.I.”

Quinn Slack (CEO) and Thorsten Ball (Amp Dictator) from SourceGraph join the show to talk about Amp Code, how they ship 15x/day with no code reviews, and why subagents and prompt optimizers aren’t a promising direction for coding agents. Amp Code: https://ampcode.com/ Latent Space: https://latent.space/ 00:00 Introduction 00:41 Transition from Cody to Amp 03:18 The Importance of Building the Best Coding Agent 06:43 Adapting to a Rapidly Evolving AI Tooling Landscape 09:36 Dogfooding at Sourcegraph 12:35 CLI vs. VS Code Extension 21:08 Positioning Amp in Coding Agent Market 24:10 The Diminishing Importance of Model Selectors 32:39 Tooling vs. Harness 37:19 Common Failure Modes of Coding Agents 47:33 Agent-Friendly Logging and Tooling 52:31 Are Subagents Real? 56:52 New Frameworks and Agent-Integrated Developer Tools 1:00:25 How Agents Are Encouraging Codebase and Workflow Changes 1:03:13 Evolving Outer Loop Tasks 1:07:09 Version Control and Merge Conflicts in an AI-First World 1:10:36 Rise of User-Generated Enterprise Software 1:14:39 Empowering Technical Leaders with AI 1:17:11 Evaluating Product Without Traditional Evals 1:20:58 Hiring