🇺🇸 United States Episodes

In this episode, my guest is Robert Malenka, MD, PhD, a professor of psychiatry and behavioral sciences at Stanford School of Medicine who has made numerous seminal discoveries of how the brain changes (neuroplasticity) in response to learning and in response to rewarding and reinforcing experiences. We discuss the brain’s several reward systems involving dopamine and serotonin and how these motivate us to seek out specific behaviors and substances. We discuss how these reward systems are modified based on context and our memories, and how they can be hijacked toward maladaptive drug seeking in addiction. We also explore how reward systems influence social connections, oxytocin and empathy and how that applies to our understanding of autism spectrum disorders. This episode should be of interest to those interested in neuroplasticity, social bonding, addiction, autism, learning and motivation. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Robert Malenka (00:02:53) Sponsors: LMNT & Waking Up (00:05:21) Dopamine & Reward Circuitry (00:11:31) Reward, Arousal, Memory & Dopamine  (00:17:34) Context, Cues & Dopamine Modification (00:25:38) Memory & Reward Scaling (00:30:50) Dopamine, “Addictive Liability” & Route of Administration  (00:39:25) Sponsor: AG1 (Athletic Greens) (00:40:40) Drugs of Abuse & Brain Changes; Addiction & Individual Variability (00:50:51) Reinforcement vs. Reward, Wanting vs. Liking (00:57:500 Opioids, Psychostimulants & Dopamine (01:04:51) Self-Doubt, Confidence & Career (01:12:40) Autism Spectrum Disorder (01:19:29) Pro-Social Interaction & Reward; Oxytocin, Serotonin & Dopamine (01:30:30) Nucleus Accumbens & Behavior Probability (01:38:28) Reward for Pro-Social Behavior (01:43:13) Social Media & “Addictive Liability”; Gambling (01:52:17) Pain, Social Behavior & Empathy (02:02:19) Empathy Circuitry, Dopamine & Serotonin  (02:10:07) Autism Spectrum Disorder & Social Interactions, Empathy (02:17:23) MDMA, Serotonin & Dopamine; Addiction & Pro-Social Effects (02:28:13) Autism Spectrum Disorder, Social Behavior, MDMA & Pharmacology (02:37:18) Serotonin, MDMA & Psychedelics  (02:40:16) Psychedelics: Research & Therapeutic Potential (02:47:57) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices

Happy 3rd Birthday, SmartLess! On another trip around the sun, a limerick for our guest:   There once was a lad named Tom Holland, Who graced a podcast, all smart(less) and grand. With laughter and charm, He caused quite the alarm, As fans tuned in from every land. Please support us by supporting our sponsors.

Chris Bumstead is a professional bodybuilder, 4X Mr. Olympia Classic Physique title holder, and a business owner. Chris is one of the greatest bodybuilders of all time. He's been called the Arnold Schwarzenegger of his era. But just what does it take to become the best in the world? What is the inner texture of a world champion like when he's as open as Chris about his failings and vulnerabilities? Expect to learn why pressure is a privilege, what it means to have a champions mentality, how Chris overcame his battle with anxiety, why he broke down sobbing on the bathroom floor 6 weeks before he won a world championship, how Chris thinks the modern world of bodybuilding compares to the golden days with Arnold, which steroid is so toxic that even Chris refuses to take, his top 10 exercises to build more muscle and much more... Sponsors: Get £150 discount on Eight Sleep products at https://eightsleep.com/modernwisdom (discount automatically applied) Get a Free Sample Pack of all LMNT Flavours with your first box at https://www.drinklmnt.com/modernwisdom (automatically applied at checkout) Get 5 Free Travel Packs, Free Liquid Vitamin D and more from AG1 at https://drinkag1.com/wisdom (discount automatically applied)  Extra Stuff: Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ Learn more about your ad choices. Visit megaphone.fm/adchoices

(0:00) We hacked the pod! Jcal is on vaca (5:34) Meta launches Threads (17:15) Chat AI interest in decline? (28:36) Fed meeting minutes, economic data and outlook, and EU risk (56:07) Florida Senate Bill 1718, jobs, and immigration debate (1:21:48) Chinese balloon: political farce? (1:31:47) Gerstner Science Corner: preventative heart health Follow the besties: https://twitter.com/chamath https://linktr.ee/calacanis https://twitter.com/DavidSacks https://twitter.com/friedberg Follow the pod: https://twitter.com/theallinpod https://linktr.ee/allinpodcast Intro Music Credit: https://rb.gy/tppkzl https://twitter.com/yung_spielburg Intro Video Credit: https://twitter.com/TheZachEffect

Is a walk through the city as good as a walk through the woods? Who’s most likely to die while taking a selfie? And how does Angela protect herself from the beer cans falling onto her deck?

Mike Israetel is a bodybuilding and fitness consultant, Temple University professor of Exercise Science, co-founder of Renaissance Periodization and author. There are thousands of videos online about what it means to be happy and successful, usually all with different conclusions, but most include wealth in some form or another. Expect to learn why a pessimistic view of life is unrealistic, the extent to which money can buy you happiness, why living in the present moment is overrated, if trading your time for future gains is a smart move, how to find purpose even in jobs you hate, whether worrying about the future will help you be more successful, Mike’s contrarian view on porn, the future of how AI will shape society and much more.... Sponsors: Get an exclusive discount from Surfshark VPN at https://surfshark.deals/MODERNWISDOM (use code MODERNWISDOM) Go to https://betterhelp.com/modernwisdom for 10% off your first month of therapy with BetterHelp and get matched with a therapist who will listen and help Get 15% discount on Mud/Wtr at http://mudwtr.com/mw (use code MODERNWISDOM)  Extra Stuff: Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ Learn more about your ad choices. Visit megaphone.fm/adchoices

When it comes to big questions about the economy, we're still kind of in the dark ages. Why do some economies grow so much faster than others? How long is the next recession going to last? How do we stop inflation without wrecking the rest of the economy? These questions are the domain of macroeconomics. But even some macroeconomists themselves admit: While we have many theories about how the economy works, we have very few satisfying answers.Emi Nakamura wants to change all that. She's a superstar economist who is a pioneer in the field of "empirical macroeconomics." She finds clever ways of using data to untangle some of the oldest mysteries in macroeconomics, about the invisible hand, the consequences of government spending, and the inner workings of inflation.Recently we called her up to ask her why the economy is so difficult to understand in first place, and how she's trying to find answers anyway. She gets into all of that, and how Jeff Goldblum shaped her career as an economist, in this episode. This show was hosted by Jeff Guo and Nick Fountain. It was produced by Dave Blanchard with help from Sam Yellowhorse Kesler. It was engineered by Josephine Nyounai and fact checked by Sierra Juarez. Keith Romer edited the show. Alex Goldmark is our executive producer.Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Education activist and 2023 Audacious Project grantee Angeline Murimirwa knows the power of educating girls, especially in places where they may not have easy access to schooling. But she says that's not enough. In an inspiring talk, she clarifies why a support network around girls -- from the moment they enter the classroom to years after they graduate -- makes a radical difference for their lives in school and beyond. Learn how how her nonprofit CAMFED is building a sisterhood to do just that. (This ambitious idea is a part of the Audacious Project, TED's initiative to inspire and fund global change.) Hosted on Acast. See acast.com/privacy for more information.

Robert F. Kennedy Jr. is an activist, lawyer, author, and candidate for the President of the Unites States. Please support this podcast by checking out our sponsors: – House of Macadamias: https://houseofmacadamias.com/lex and use code LEX to get 20% off your first order – Eight Sleep: https://www.eightsleep.com/lex to get special savings – InsideTracker: https://insidetracker.com/lex to get 20% off – AG1: https://drinkag1.com/lex to get 1 month supply of fish oil TRANSCRIPT: https://lexfridman.com/robert-f-kennedy-jr-transcript/ EPISODE LINKS: Robert’s Twitter: https://twitter.com/RobertKennedyJr Robert’s Instagram: https://www.instagram.com/robertfkennedyjr Robert’s Facebook: https://www.facebook.com/rfkjr Robert’s Campaign Website: https://www.kennedy24.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/lexfridman – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (09:05) – US history (13:21) – Freedom (15:16) – Camus (18:38) – Hitler and WW2 (27:50) – War in Ukraine (51:11) – JFK and the Cuban Missile Crisis (1:16:19) – JFK assassination conspiracy (1:25:53) – CIA influence (1:34:52) – 2024 elections (1:46:36) – Jordan Peterson (1:48:18) – Anthony Fauci (1:51:44) – Big Pharma (2:11:24) – Peter Hotez (2:17:05) – Exercise and diet (2:19:30) – God

Remote work is a big, divisive topic right now. Some think it’s the future, while others think it was an experiment gone wrong. But it’s also not the only way to attract top talent. And the equation for doing so has only gotten more confusion as a myriad of trends intersect, from layoffs to emerging technologies like AI. So how can companies navigate this storm and truly attract the talent that matters? Listen in to find out.

Joe is joined by Sean Strickland, a professional mixed martial artist competing in the middleweight division of the Ultimate Fighting Championship.  www.ufc.com/athlete/sean-strickland Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episode 472: Sam Parr (@TheSamParr) and Shaan Puri (@ShaanVP) unveil their list of the best companies making more than $1M annually with no full time employees. Want to see more MFM? Subscribe to the MFM YouTube channel here. ----- Check Out Sam's Stuff: * Hampton * Ideation Bootcamp * Copy That Check Out Shaan's Stuff: * Try Shepherd * Shaan's Personal Assistant System * Power Writing Course * Daily Newsletter ----- Show Notes: (00:00) - Introduction (03:50) - Biggest One-Person Business - Stardew Valley, Streamyard, and Plenty of Fish (15:45) - Highest Degree of Difficulty - TinyWow and Photopea (26:00) - Easiest to Recreate: GetCyberLeads, Lenny Rachitsky, and Marketing Examples (36:00) - Most Fun: Joe Rogan and Gym Streak (42:00) - Business You Would Most Want to Own: Milled and BuiltWith (46:30) - Rookie of the Year: Joseph Mambwe and Only Finder (55:30) - Worst of the Best: The Van Trump Report ------ Links: * Stardew Valley * Streamyard * Plenty of Fish * TinyWow * Photopea * GetCyberLeads * Lenny Rachitsky * Marketing Examples * Gym Streak * Milled * BuiltWith * Hampton Blog on Joseph Mambwe * OnlyFinder * Van Trump Report * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. ------ Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. ----- Additional episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto * #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

Instagram is no stranger to taking product ideas from other companies and turning them into their own successes. Just ask Snapchat about Instagram Stories or TikTok about Instagram Reels. This time, the company is coming for Twitter with Instagram Threads. Today, the head of Instagram, Adam Mosseri, on why the company now wants to take on Twitter.

Human beings are social creatures, with a critical need to connect with others. This drive gives shape and meaning to our personal and professional lives. For entrepreneurs and business leaders, the path to success relies on strong, human-centered networks. In this special episode, we revisit the Masters of Scale Summit to hear from leaders, including our very own Reid Hoffman, who share inside stories on how to build — and nurture — professional and personal networks. Learn how to network with authenticity, multiply the positive attributes of your network, and recognize your own biases to prevent blind spots on your journey to scale.Read a transcript of this episode: https://mastersofscale.com/Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

We had a wicked pissah with "the opposite of Tom Brady" a.k.a. Conan O'Brien. (Recorded on February 04, 2022)

Geoffrey Miller is a professor of evolutionary psychology at the University of New Mexico, a researcher and an author. Artificial Intelligence possesses the capability to process information thousands of times faster than humans. It's opened up massive possibilities. But it's also opened up huge debate about the safety of creating a machine which is more intelligent and powerful than we are. Just how legitimate are the concerns about the future of AI? Expect to learn the key risks that AI poses to humanity, the 3 biggest existential risks that will determine the future of civilisation, whether Large Language Models can actually become conscious simply by being more powerful, whether making an Artificial General Intelligence will be like creating a god or a demon, the influence that AI will have on the future of our lives and much more...  Extra Stuff: Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Two stories today.First, as we start to understand post-affirmative action America, we look to a natural experiment 25 years ago, when California ended the practice in public universities. It reshaped the makeup of the universities almost instantly. We find out what happened in the decades that followed.Then, we ask, why does it cost so much for America to build big things, like subways. Compared to other wealthy nations, the costs of infrastructure projects in the U.S. are astronomical. We take a trip to one of the most expensive subway stations in the world to get to the bottom of why American transit is so expensive to build.This episode was hosted by Adrian Ma and Darian Woods. It was produced by Corey Bridges, and engineered by Robert Rodriguez and Katherine Silva. It was fact-checked by Sierra Juarez. Viet Le is the Indicator's senior producer. And Kate Concannon edits the show. Alex Goldmark is our executive producer.Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Joe is joined by retired mixed martial artists Matt Serra, Din Thomas & John Rallo. Matt is the co-host of the "UFC Unfiltered" podcast with Jim Norton, and founder and lead instructor of Serra BJJ. Din is the co-host of "After TUF" and host of the "Din's Got Answers" podcast. John is the owner and head coach at Ground Control mixed martial arts academy in Baltimore.  www.serrabjj.com www.ufc.com/athlete/din-thomas https://www.groundcontrolbaltimore.com/ Learn more about your ad choices. Visit podcastchoices.com/adchoices

We tend to think of evolution as a slow, gradual process playing out over millions of years. But evolutionary biologist Shane Campbell-Staton says nature is now changing at breakneck speed to keep up with the world humanity has built. From tuskless elephants who escape poachers to wolves living in the radioactive Chernobyl Exclusion Zone, Campbell-Staton unpacks how life is rapidly adapting in surprising ways -- and asks us to rethink how we can protect the planet's biodiversity. Hosted on Acast. See acast.com/privacy for more information.

Oprah sits down with New York Times bestselling author Dr. Abraham Verghese for a compelling six-part conversation on his latest book, The Covenant of Water. In this episode, they discuss parts 3 and 4 and how the unlikely meeting of two characters in part 4 signals a major turning point. They also talk about why Abraham decided to make leprosy the centerpiece of the story. Want more podcasts from OWN? Visit https://bit.ly/OWNPods You can also watch Oprah’s Super Soul, The Oprah Winfrey Show and more of your favorite OWN shows on your TV! Visit https://bit.ly/find_OWN