🇺🇸 United States Episodes

Announcing a16z Journal Club, a new show where we curate and discuss recent research papers with a16z experts and others. The first episode is of bio journal club, which focuses on why specific scientific advances matter from our perspective at the intersection of biology & technology.

Pet adoptions have soared during the coronavirus lockdown, as people seek companionship and solace. For Chewy, the pet-supply company, that’s driving unprecedented demand. Ultra-rapid growth has its own set of challenges that CEO Sumit Singh is responding to by: hiring (at 13,000 employees, with plans to add another 6,000 to 10,000 by end of year); setting up a COVID task team that meets daily; instituting health and safety checks; rolling out customer-facing innovations in a weekend, and more. Why? Because a leader's job during a crisis, Singh says, is to first communicate with the team, and then innovate for a post-pandemic world. Interviewed by editor Bob Safian.Read a transcript of this episode: https://mastersofscale.comSubscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's ep is possible because of Superside! Head to superside.com to hire a dedicated team of designers! Sam (@thesamparr) and Shaan (@shaanvp) are back to talk about Burning money (0:36), Asia monetizing podcasts way better / paid news (3:23), Drudge report getting 1.1 billion visits a month?! (11:28), Neil Patel and where most enterprise revenue coming from maintenance (20:59), Book a YC team (29:17), Remote.com raising $11M seed (33:19), Attrition projection/modelling (37:52) and Yishan Wong solving climate change (41:08).  See acast.com/privacy for privacy and opt-out information.

Duncan Trussell is a stand-up comedian, and host of his own podcast “The Duncan Trussell Family Hour” available on Spotify. His new show “The Midnight Gospel” is now streaming only on Netflix. @Duncan Trussell Learn more about your ad choices. Visit podcastchoices.com/adchoices

Jack Dorsey is the co-founder and CEO of Twitter and the founder and CEO of Square. Support this podcast by signing up with these sponsors: – MasterClass: https://masterclass.com/lex EPISODE LINKS: Jack’s Twitter: https://twitter.com/jack Start Small Tracker: https://bit.ly/2KxdiBL This conversation is part of the Artificial Intelligence podcast. If you would like to get more information about this podcast go to https://lexfridman.com/ai or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon. Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time. OUTLINE: 00:00 – Introduction 02:48 – Engineering at scale 08:36 – Increasing access to the economy 13:09 – Machine learning at Square 15:18 – Future of the digital economy 17:17 – Cryptocurrency 25:31 – Artificial intelligence 27:49 – Her 29:12 – Exchange with Elon Musk about bots 32:05 – Concerns about artificial intelligence 35:40 – Andrew Yang 40:57 – Eating one meal a day 45:49 – Mortality 47:50 – Meaning of life 48:59 – Simulation

Today’s episode is one of our intimate hallway-style conversations — or as intimate as remote work allows anyway. It’s all about the history and future of protocol development. a16z crypto partner Ali Yahya, formerly Distributed Systems & Machine Learning researcher at Stanford & Google Brain, wrote a tweetstorm earlier this year about the “Narrow Waist of Blockchain Computing” (we link to in the show notes). Ali observed that the Internet Protocol, which emerged out of research labs and government funding decades ago, has taken the world from zero devices to more than 15 billion connected devices today. What was it about the Internet Protocol that allowed building so many applications on top? Helping us answer this question is a16z general partner in enterprise Martin Casado, who pioneered software-defined networking. He co-founded Nicira, which was acquired by VMware; and then he led their Networking and Security Business Unit, which he scaled to a hugely successful business, so he knows a thing or two about this topic. The two debate the tension between bottom-up design and top-down architected approaches to internet applications, including the role of standards bodies. More broadly, their discussion is about how innovation plays out in practice, and they end by sharing advice for entrepreneurs today. But they begin with a quick history and description of the “Narrow Waist,” and the conditions that create it:

Examining the facts and figures of the coronavirus outbreak, epidemiologist Larry Brilliant evaluates the global response in a candid interview with head of TED Chris Anderson. Brilliant lays out a clear plan to end the pandemic -- and shows why, to achieve it, we'll have to work together across political and geographical divides. "This is not the zombie apocalypse; this is not a mass extinction event," he says. "We need to be the best version of ourselves." (Recorded April 22, 2020) Hosted on Acast. See acast.com/privacy for more information.

Stephen Dubner, the host of Freakonomics Radio, and Angela Duckworth, the psychologist and author of Grit, explore the weird and wonderful ways in which humans behave. In each episode, they take turns asking each other questions, with conversations ranging from friendship and parenting to immortality and whether dogs are better than people. No Stupid Questions premieres May 18th.

A neighborhood is more than just the people who share a common address, says Nextdoor CEO Sarah Friar. It’s every space that makes up your daily life. So Nextdoor is jumping in, rolling out new features like Help Maps and Groups so residents can connect and coordinate. Sarah says these products, some new, some in development pre-Covid, all help fulfill Nextdoor’s mission and help neighbors act as the frontline of support for one another.Read a transcript of this episode: https://mastersofscale.comSubscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Tom Green is a comedian, actor, filmmaker, and talk show host. He is the host of the podcast "The Tom Green Podcast" available on Spotify. @Tom Green ​ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Improv advice on getting out of our heads and into the present moment.

In the US, local governments are leading the response to COVID-19 – making decisions and gathering data at a speed and scale never before seen. And many of them are asking Jen Pahlka for help. The founder and past chair of Code for America, she co-founded U.S. Digital Response, a nonpartisan group that matches experts with local governments to work on tech, comms and operations. She shares what she's seeing right now – and paints a bold, big-picture vision of what a modern government could do in the years to come. Interviewed by editor Bob Safian.Read a transcript of this episode: https://mastersofscale.comSubscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When it comes to big life problems, we often stand at a crossroads: either believe we're powerless against great change, or we rise to meet the challenge. In an urgent call to action, political strategist Tom Rivett-Carnac makes the case for adopting a mindset of "stubborn optimism" to confront climate change -- or whatever crisis may come our way -- and sustain the action needed to build a regenerative future. As he puts it: "Stubborn optimism can fill our lives with meaning and purpose." Hosted on Acast. See acast.com/privacy for more information.

Dr Sam Spinelli is a Doctor of Physical Therapy and Strength & Conditioning Expert. The first thing you do before any workout is warm up, but understanding the specifics of how an effective warmup routine is designed is unknown by most of us. Expect to learn the key principles behind designing your warmup routine, which movements bring the greatest returns for upper & lower, how to improve your overhead position, deepen your squat, save time and stay resilient. Do not miss this one. Check out everything I use from The Protein Works and get 35% OFF SITE WIDE with the code MODERN35 - https://www.theproteinworks.com/modernwisdom/ Extra Stuff: Check out Dr Spinelli's Website - https://www.thestrengththerapist.com/ Follow Dr Spinelli on Instagram - https://www.instagram.com/dr.samspinelli/ Take a break from alcohol and upgrade your life - https://6monthssober.com/podcast Check out everything I recommend from books to products - https://www.amazon.co.uk/shop/modernwisdom - Get in touch. Join the discussion with me and other like minded listeners in the episode comments on the MW YouTube Channel or message me... Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/ModernWisdomPodcast Email: https://www.chriswillx.com/contact Learn more about your ad choices. Visit megaphone.fm/adchoices

Kurt Metzger is a comedian, actor and writer.  He also has a podcast called “Can't Get Right" on Spotify. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dmitry Korkin is a professor of bioinformatics and computational biology at Worcester Polytechnic Institute, where he specializes in bioinformatics of complex disease, computational genomics, systems biology, and biomedical data analytics. I came across Dmitry’s work when in February his group used the viral genome of the COVID-19 to reconstruct the 3D structure of its major viral proteins and their interactions with human proteins, in effect creating a structural genomics map of the coronavirus and making this data open and available to researchers everywhere. We talked about the biology of COVID-19, SARS, and viruses in general, and how computational methods can help us understand their structure and function in order to develop antiviral drugs and vaccines. Support this podcast by signing up with these sponsors: – Cash App – use code “LexPodcast” and download: – Cash App (App Store): https://apple.co/2sPrUHe – Cash App (Google Play): https://bit.ly/2MlvP5w EPISODE LINKS: Dmitry’s Website: http://korkinlab.org/ Dmitry’s Twitter: https://twitter.com/dmkorkin Dmitry’s Paper that we discuss: https://bit.ly/3eKghEM This conversation is part of the Artificial Intelligence podcast. If you would like to get more information about this podcast go to https://lexfridman.com/ai or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon. Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time. OUTLINE: 00:00 – Introduction 02:33 – Viruses are terrifying and fascinating 06:02 – How hard is it to engineer a virus? 10:48 – What makes a virus contagious? 29:52 – Figuring out the function of a protein 53:27 – Functional regions of viral proteins 1:19:09 – Biology of a coronavirus treatment 1:34:46 – Is a virus alive? 1:37:05 – Epidemiological modeling 1:55:27 – Russia 2:02:31 – Science bobbleheads 2:06:31 – Meaning of life

If you had to explain to a newborn -- or an alien -- what it means to be a human being living on Earth in the 21st century, what would you say? Visual artist Oliver Jeffers put his answer in a letter to his son, sharing pearls of wisdom on existence and the diversity of life. He shares observations of the "beautiful, fragile drama of human civilization" in this poetic talk paired with his original illustrations and animations. Hosted on Acast. See acast.com/privacy for more information.

Sam (@thesamparr) and Shaan (@shaanvp) chilling on Zoom once again to talk about Marc Andreessen's new controverisal blog post titled "It's Time To Build" (3:54), On Deck - MBA As A Service (17:27), Founder Dating (27:35), Talking to Naval on ClubHouse (36:37), Oatley's Milk is bomb af (45:08), Fastgrants.org (51:31) and Shaan's Degenerate Crypto Trade (53:38)  See acast.com/privacy for privacy and opt-out information.

Former All-American athlete, world-renowned fitness expert and celebrity trainer, Angela Manuel Davis, joins WW presents Oprah’s 2020 Vision: Your Life in Focus Tour for a talk in front of a live audience in St. Paul, Minnesota. Angela opens up about a difficult divorce and post-partum depression. Angela explains how she uses her body to helpf fulfill her life’s intention. She shares what wellness means to her, why we should pay attention to the words we say and discusses what she believes is the difference between vision and sight. Angela also leads the audience in what she calls a vision activation exercise.

Many of us will be working remotely for a long time to come. So: How do you turn March's temporary scramble into a long-term benefit? Bitcoin pioneer Wences Casares runs a fully distributed company at his unicorn bitcoin startup, Xapo. For Wences, remote work is an intentional choice, one that celebrates the creativity and freedom of being released from geographical boundaries – and turns remote work into a striking advantage. Hear Xapo's battle-tested guidelines for communication styles, hiring – and supporting home offices that really work.Read a transcript of this episode: https://mastersofscale.comSubscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.