🇺🇸 United States Episodes

My guest today is D.A. Wallach, one of the more interesting investors I’ve come across. He is the former lead singer of the group Chester French and the former artist-in-residence at Spotify, where he was also an early investor. While he’s also an early investor in companies like SpaceX, his focus the last 5 years has been on early stage health care investing, which is the topic of this conversation. We discuss the entire life sciences and heath care investing ecosystem. This was recorded in the very early days of the Coronavirus outbreak so while we touch on it briefly it isn’t the primary focus, and I intend on returning to more traditional episodes like this one in the coming weeks, meant to be evergreen conversations. Please enjoy my conversation with D.A. Wallach. For more episodes go to InvestorFieldGuide.com/podcast. Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub. Follow Patrick on Twitter at @patrick_oshag   Show Notes 1:31 – (First question) – Where is interest in healthcare started 4:04 – How to categorize health services 5:13 – The product of medicine 6:56 – How medicine is changing in 2020 10:17 – What is enabling innovation in medicine 12:41 – Manufacturing of solutions, gene therapy example 17:16 – Using CRISPR 19:47 – Pros and cons, and the morality of gene intervention 23:44 – How progress is being made in medical breakthroughs 26:51 – What is the business and investment world seeing on the longevity side 30:15 – What is next in the wearable medical tracking trend 33:04 – The personalization of medical treatments 34:31 – How he thinks about all of this from an investing standpoint 36:37 – Exiting these companies 39:41 – How he thinks about founders in this space 42:35 – Drug prices             42:46 – The Paradox of Pricing 46:45 – What will lead to a change in the pricing of drugs 49:05 – The delivery side of healthcare 51:09 – Investments that could improve the delivery side of healthcare 53:33 – Thoughts on the anti-interventionist line of thinking in the medical world 57:50 – Lessons from his health portfolio 1:02:33 – Other frontiers that pique his interest, including gut biome 1:06:46 – His career in music 1:08:20 – Lessons he learned during his time in the music industry 1:10:19 – Opportunities in the music industry as an investor 1:12:29 – Kindest thing anyone has done for DA   Learn More For more episodes go to InvestorFieldGuide.com/podcast.  Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub Follow Patrick on Twitter at @patrick_oshag

On March 5th 2020, Sequoia Capital published a Medium post entitled ‘Coronavirus: The Black Swan of 2020’. The memo minces no words, admonishing founders & CEOs to “question every assumption about your business”, and portends that “as Darwin surmised, those who [will] survive ‘are not the strongest or the most intelligent, but the most adaptable to change.’” We’re joined by longtime Sequoia partner and head of the firm’s US business Roelof Botha to discuss on what Sequoia saw leading up to the memo and why they decided to publish it, how they and their portfolio companies are adapting to the new world it warned of, and what lasting changes might come to Sequoia itself from this moment. For anyone facing hard decisions and/or looking for ways to think about opportunity, this is not one to miss. Sponsors:Rippling: https://bit.ly/acquiredripplingStatsig: https://bit.ly/acquiredstatsig25Odd Lots: https://bit.ly/acquiredoddlotsServiceNow: https://bit.ly/acquiredsnMore Acquired!Get email updates with hints on next episode and follow-ups from recent episodesJoin the SlackSubscribe to ACQ2Merch Store!© Copyright 2015-2025 ACQ, LLCLinks:The Black Swan Memo:  https://medium.com/sequoia-capital/coronavirus-the-black-swan-of-2020-7c72bdeb9753 The COVID-19 Decision Matrix:  https://medium.com/sequoia-capital/the-matrix-for-covid-19-c25bd5195f46 

Brian Redban is a comedian and the founder of the Deathsquad podcast network. Also look for him on "Kill Tony" available on Spotify under "Deathsquad". Learn more about your ad choices. Visit podcastchoices.com/adchoices

Sam (@thesamparr) and Shaan (@shaanvp) today go over more YC batch companies! Sign up to the new Trends report that Sam mentioned at https://trends.co. Today's topics: Sam might have corona virus (5:46), is YC better this year going digital? (10:15), Smile Direct Club for Latin America (14:56), Education in India (17:56), EzeWholesale - Marketplace for Used Phones (23:28), Offerup and LetGo Merger (28:13), Build a Plane - Project Management for Construction (30:03), Strippers leaving their jobs to become delivery drivers (34:24), Ditto - Collaborative copywriting tool (38:12), Shaan's marketing intern challenge (46:14), Ugly food delivery services (48:49), Automating collections using Upflow (52:52), Teiv - Adblock for in-store TV's (58:31)  See acast.com/privacy for privacy and opt-out information.

Pardons, commutations and bankruptcy laws are all tools of forgiveness within the US legal system. Are we using them frequently enough, and with fairness? Law professor Martha Minow outlines how these merciful measures can reinforce racial and economic inequality -- and makes the case for creating a system of restorative justice that focuses on accountability and reconciliation rather than punishment. Hosted on Acast. See acast.com/privacy for more information.

Steven Fawcett is a 3 Times CrossFit Games Athlete and Head Coach of JST Compete. How to become fit and how to use that fitness in a competitive environment are two very different challenges. Many athletes will spend years training and competing to see their numbers stay the same, or maybe even go backwards. So what's the solution? As a coach and athlete who has seen phenomenal success over the last few years, I figured Ste would be a good guy to ask. Expect to learn how to periodise your training, how often you should be competing every year, why a full break can be one of the best training tools you can use, what Ste's best advice is on competition weekends and much more. Check out everything I use from The Protein Works and get 35% OFF SITE WIDE with the code MODERN35 - PLUS get a FREE Pouch of Protein with your first order - https://www.theproteinworks.com/modernwisdom/ Extra Stuff: Check out JST Compete - http://www.jstcompete.com/ Follow JST Compete on Instagram - https://www.instagram.com/jst_compete/ Follow Ste on Instagram - https://www.instagram.com/steveyf22 Take a break from alcohol and upgrade your life - https://6monthssober.com/podcast Check out everything I recommend from books to products - https://www.amazon.co.uk/shop/modernwisdom - Get in touch. Join the discussion with me and other like minded listeners in the episode comments on the MW YouTube Channel or message me... Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/ModernWisdomPodcast Email: https://www.chriswillx.com/contact Learn more about your ad choices. Visit megaphone.fm/adchoices

A hiring platform for nurses in the U.S. used by hospitals and health systems that helps hospitals find nurses faster, offers free continuing education to nurses everywhere, and puts nurses at the center. with @imanabuzeid @bhorowitz @shakasenghor

This is the next cycle of Hustlin' Tech, a podcast series about technology platforms that create opportunities for people. Recorded right before the coronavirus pandemic, these next 3 episodes touch on many things that are top of mind right now: from the profession of nursing; to taking care of the elderly; and fighting bureaucracy to get money back -- or to get help delaying utility bills and rent payments that are eligible for an extension or waiver of late fees due to the crisis.

We are in the midst of a rapid and unprecedented shift to remote work, what does this mean for security? How prepared are organizations? And what should each of us do to stay secure?

Become a more effective and engaging online communicator.

From Hong Kong, South China Morning Post CEO Gary Liu tracks China’s response to the coronavirus pandemic -- from the initial outbreak in Wuhan to the shutdown of Hubei province and the containment measures taken across its major cities. Sharing insights into how the culture in places like Hong Kong and South Korea contributed to fast action against the virus, Liu identifies lessons people across the world can use to stop its spread. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers.) Hosted on Acast. See acast.com/privacy for more information.

Bryan Callen is an actor and stand-up comedian, and together with Brendan Schaub he also hosts “The Fighter & The Kid” podcast available on Spotify. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Can you blitzscale when the world grinds to a halt? How do you do right by your team AND your investors? What will the entrepreneurial world look like on the other side of this? In this special episode, our host Reid Hoffman, sits on the other side of the mic, contextualizing the crisis and offering a hopeful viewpoint. Interviewed by editor Bob Safian.Read a transcript of this episode: https://mastersofscale.comSubscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What's your passion? Social entrepreneur Noeline Kirabo reflects on her work helping out-of-school young people in Uganda turn their passions into profitable businesses -- and shares the two questions you can ask yourself to begin doing the same. Hosted on Acast. See acast.com/privacy for more information.

In 1976, broadcast journalist Oprah Winfrey moved to Baltimore to coanchor the evening newscast at a local TV station. But she struggled in that spot and was moved to the morning talk show. That demotion led Winfrey to discover a professional calling that aligned with her personal sensibilities and emerging strengths. In the final episode of a four-part special series on leadership, HBR Editor in Chief Adi Ignatius and Harvard Business School professor and historian Nancy Koehn trace Winfrey’s career as an entrepreneur and leader of a media empire. They discover lessons on how to cultivate self-awareness, cross traditional boundaries, and responsibly wield influence.

Jason Calacanis is an angel investor and podcaster. I'm constantly hearing stories of how people are making their millions and billions angel investing in Silicon Valley startups, but I have no idea how it all works. Thankfully I got hold of Jason, who was one of the first investors in Uber, Thumbtack, Calm and many more, to teach us everything there is to know about the industry. Get Surfshark VPN - https://surfshark.deals/MODERNWISDOM (Enter Promo Code MODERNWISDOM for 83% off & One Extra Month Free) Extra Stuff: Follow Jason on Twitter - https://twitter.com/jason Check out Jason's Company - https://launch.co/ Take a break from alcohol and upgrade your life - https://6monthssober.com/podcast Check out everything I recommend from books to products - https://www.amazon.co.uk/shop/modernwisdom - Get in touch. Join the discussion with me and other like minded listeners in the episode comments on the MW YouTube Channel or message me... Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/ModernWisdomPodcast Email: https://www.chriswillx.com/contact Learn more about your ad choices. Visit megaphone.fm/adchoices

Nick Bostrom is a philosopher at University of Oxford and the director of the Future of Humanity Institute. He has worked on fascinating and important ideas in existential risks, simulation hypothesis, human enhancement ethics, and the risks of superintelligent AI systems, including in his book Superintelligence. I can see talking to Nick multiple times on this podcast, many hours each time, but we have to start somewhere. Support this podcast by signing up with these sponsors: – Cash App – use code “LexPodcast” and download: – Cash App (App Store): https://apple.co/2sPrUHe – Cash App (Google Play): https://bit.ly/2MlvP5w EPISODE LINKS: Nick’s website: https://nickbostrom.com/ Future of Humanity Institute: – https://twitter.com/fhioxford – https://www.fhi.ox.ac.uk/ Books: – Superintelligence: https://amzn.to/2JckX83 Wikipedia: – https://en.wikipedia.org/wiki/Simulation_hypothesis – https://en.wikipedia.org/wiki/Principle_of_indifference – https://en.wikipedia.org/wiki/Doomsday_argument – https://en.wikipedia.org/wiki/Global_catastrophic_risk This conversation is part of the Artificial Intelligence podcast. If you would like to get more information about this podcast go to https://lexfridman.com/ai or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon. Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time. OUTLINE: 00:00 – Introduction 02:48 – Simulation hypothesis and simulation argument 12:17 – Technologically mature civilizations 15:30 – Case 1: if something kills all possible civilizations 19:08 – Case 2: if we lose interest in creating simulations 22:03 – Consciousness 26:27 – Immersive worlds 28:50 – Experience machine 41:10 – Intelligence and consciousness 48:58 – Weighing probabilities of the simulation argument 1:01:43 – Elaborating on Joe Rogan conversation 1:05:53 – Doomsday argument and anthropic reasoning 1:23:02 – Elon Musk 1:25:26 – What’s outside the simulation? 1:29:52 – Superintelligence 1:47:27 – AGI utopia 1:52:41 – Meaning of life

Joey “CoCo” Diaz is a Cuban-American stand up comedian and actor. Joey also hosts his own podcast called “The Church of What’s Happening Now” available on Spotify. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Philanthropist and Microsoft cofounder Bill Gates offers insights into the COVID-19 pandemic, discussing why testing and self-isolation are essential, which medical advancements show promise and what it will take for the world to endure this crisis. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers.) Hosted on Acast. See acast.com/privacy for more information.

The spike in online ordering and food delivery—a trend that's particularly relevant now—is evidence of how tech is fundamentally changing how and what we eat. In this conversation between Virtual Kitchen Co. CEO Ken Chong, Snackpass CEO Kevin Tan, a16z general parter Andrew Chen, and host Lauren Murrow, we discuss what's driving this transformation, as well as its implications for the future of dining and cooking. Is this the end of the traditional restaurant experience as we know it?