🇺🇸 United States Episodes

CAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer, has been so effective in childhood leukemias that we believe it may actually be a potential cure. But this isn't just one new medicine, it's an entirely new therapeutic tool—and a total paradigm shift from most traditional medicines we've seen before.

Imagine waking in the middle of the night to an elephant ripping the roof from your house in search of food. This is a reality in some communities in Africa where, as wild spaces shrink, people and elephants are competing for space and resources like never before. In this engaging talk, zoologist Lucy King shares her solution to the rising conflict: fences made from beehives that keep elephants at bay while also helping farmers establish new livelihoods. Hosted on Acast. See acast.com/privacy for more information.

Sam and Shaan are back talking news, trends, interesting products and businesses. The way to make a million is by surrounding yourself around other people who want it. Join our Facebook group where we share ideas and help each other out: www.facebook.com/groups/ourfirstmillion. Harry's (D2C razor brand) sale blocked & D2C selling to PE strategy (0:55), /r/WallStreetBets & Tesla shorts (6:05), Drew Houston sitting on Facebook board & Professional board sitters (11:39), Labor law posters, MailChimp for governments & other weird compliance rules (14:48), Turnkey compliance, contracting remote workers & Letsdeel.com (18:11), Huge unsexy business: exec headhunting (21:23), Influential people curating job boards (27:52), Crowd-sources salary comparison sites like levels.fyi (33:08) & The Ringer selling to Spotify & why it makes podcast acquisitions make sense (35:41).  See acast.com/privacy for privacy and opt-out information.

Garrett Reisman is a former NASA Astronaut. He is currently a Professor of Astronautical Engineering at USC and a Senior Advisor at SpaceX. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Classic episode: You need a strong culture to build a company that will scale beyond the early days of start up. And strong company cultures only emerge when every employee feels they own the culture from day one. Here's how Reed Hastings did it – and made Netflix culture (and its “culture deck”) famous in the process. Cameo appearances: Jeff Weiner (LinkedIn), Aneel Bhusri (Workday), Margaret Heffernan (entrepreneur), Tristan Walker (Walker & Co.), Mariam Naficy (Minted).Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In a profound talk about technology and power, author and historian Yuval Noah Harari explains the important difference between fascism and nationalism -- and what the consolidation of our data means for the future of democracy. Appearing as a hologram live from Tel Aviv, Harari warns that the greatest danger that now faces liberal democracy is that the revolution in information technology will make dictatorships more efficient and capable of control. "The enemies of liberal democracy hack our feelings of fear and hate and vanity, and then use these feelings to polarize and destroy," Harari says. "It is the responsibility of all of us to get to know our weaknesses and make sure they don't become weapons." (Followed by a brief conversation with TED curator Chris Anderson) Hosted on Acast. See acast.com/privacy for more information.

Michael Malice is an author, political commentator & podcaster. What happens if Biden or Bernie end up going head to head with Trump in 2020? Who created Flamin' Hot Cheetos? Why is fast fashion killing the wiping rags industry? Is it hard dating when you were once on reality TV? What is the most popular Spirit on the planet? All this & more with my new best friend, Michael. Extra Stuff: Check out The Protein Works - https://bit.ly/TPWChrisWillx Buy Michael's Book - https://amzn.to/31soCH7 Follow Michael on Twitter - https://twitter.com/michaelmalice Take a break from alcohol and upgrade your life - https://6monthssober.com/podcast Check out everything I recommend from books to products - https://www.amazon.co.uk/shop/modernwisdom - Get in touch. Join the discussion with me and other like minded listeners in the episode comments on the MW YouTube Channel or message me... Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/ModernWisdomPodcast Email: https://www.chriswillx.com/contact Learn more about your ad choices. Visit megaphone.fm/adchoices

Tom Papa is a comedian, actor, writer and television/radio host. Check out his new special "You're Doing Great!" now streaming on Netflix. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Jim Keller is a legendary microprocessor engineer, having worked at AMD, Apple, Tesla, and now Intel. He’s known for his work on the AMD K7, K8, K12 and Zen microarchitectures, Apple A4, A5 processors, and co-author of the specifications for the x86-64 instruction set and HyperTransport interconnect. This conversation is part of the Artificial Intelligence podcast. If you would like to get more information about this podcast go to https://lexfridman.com/ai or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon. This episode is presented by Cash App. Download it (App Store, Google Play), use code “LexPodcast”.  Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 – Introduction 02:12 – Difference between a computer and a human brain 03:43 – Computer abstraction layers and parallelism 17:53 – If you run a program multiple times, do you always get the same answer? 20:43 – Building computers and teams of people 22:41 – Start from scratch every 5 years 30:05 – Moore’s law is not dead 55:47 – Is superintelligence the next layer of abstraction? 1:00:02 – Is the universe a computer? 1:03:00 – Ray Kurzweil and exponential improvement in technology 1:04:33 – Elon Musk and Tesla Autopilot 1:20:51 – Lessons from working with Elon Musk 1:28:33 – Existential threats from AI 1:32:38 – Happiness and the meaning of life

Tribology: it's a funny-sounding word you might not have heard before, but it could change how you see and interact with the physical world, says mechanical engineer Jennifer Vail. Offering lessons from tribology -- the study of friction and wear -- Vail describes the surprisingly varied ways it impacts everyday life and how it could help us make a better world. Hosted on Acast. See acast.com/privacy for more information.

** In our Facebook group yet? We hang out there so come join and let's talk ideas: www.facebook.com/groups/ourfirstmillion ** Amanda Bradford (@amandabradford) was 28 years old, in business school and using dating apps. She got tired of stalking every match on Linkedin, Facebook etc.. to see if they were legit. Why doesn’t the dating app do this for me?So against all her advisors advice, she started a dating app called the League that checks your Facebook & Linkedin to verify that you are who you say you are.Strange idea, but It’s kinda working! They have over 100k paying members, profitable & been around for 5 years. We talk about: how she got her first 400 users at launch, how they figured out if people would pay $$ for subscription and what the future of dating looks like.  See acast.com/privacy for privacy and opt-out information.

Comedian, musician and co-author of He's Just Not That Into You, Greg Behrendt and his wife Amiira Ruotola explain why they believe so many women lower their standards when it comes to dating. Together, they share the biggest mistake women make in dating, what single men are really thinking and why it is important not to lower your personal standards. They also discuss their book It’s Just A F***ing Date.

Andrew Doyle is a British comedian, playwright, journalist, political satirist and is creator of the fictitious character Titania McGrath. The new book "Woke: A Guide to Social Justice" by Titania McGrath is now available: https://amzn.to/36X2GoG Learn more about your ad choices. Visit podcastchoices.com/adchoices

Who deserves to be in a museum? For too long, the answer has been "the extraordinary" -- those aspirational historymakers who inspire us with their successes. But those stories are limiting, says museum curator Ariana Curtis. In a visionary talk, she imagines how museums can more accurately represent history by honoring the lives of people both extraordinary and everyday, prominent and hidden -- and amplify diverse perspectives that should have always been included. Hosted on Acast. See acast.com/privacy for more information.

Stefan Thomke, professor at Harvard Business School, says running experiments can give companies tremendous value, but too often business leaders make decisions based on intuition. While A/B testing on large transaction volumes is common practice at Google, Booking.com, and Netflix, Thomke says even small firms can get a competitive advantage from experiments. He explains how to introduce, run, and learn from them, as well as how to cultivate an experimental mindset at your organization. Thomke is the author of the book "Experimentation Works: The Surprising Power of Business Experiments" and the HBR article "Building a Culture of Experimentation."

For the 100th episode, I’ve brought back my good friend Brent Beshore. Brent was the 10th guest on the podcast, after we met because of a mutual interest in capital allocation. I quickly learned that Brent was one of the most unique and thoughtful investors around. He was an entrepreneur from the moment he left school, trying many different things before finding a fit buying smaller business with the intention of owning them forever. What amazes me about Brent is his encyclopedic understanding of business and the nuances of different business models and deal structures. This comes from reps. He and his team have looked at about 12,000 deals over the years, at every kind of business that you could imagine. I’ve been with him when he goes through this process and it’s fun to hear what makes certain businesses stand out from others, which is largely the topic of this conversation. You all know transparency is key for me, so it’s important to know that my family and I are investors in a fund called permanent equity, run by Brent and his firm Adventure.es. To commemorate this milestone episode, I can think of no one better than Brent, because he exemplifies what has made this podcast so fun for me: learning from other people who are willing to share what they themselves have learned through fun, blood, sweat, and tears. Please enjoy our conversation, and thank you so much for coming along on this journey. I can’t tell you how much it means to me. For more episodes go to InvestorFieldGuide.com/podcast. Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub. Follow Patrick on Twitter at @patrick_oshag Show Notes 2:02 - (First Question) – How does he think about optimizing risk in terms of the capital stack when looking at deals 5:27 – What conditions would they add debt down the road after investing in a company 6:52 – What business sectors are most intriguing for Morgan to invest in right now             6:57 – Trent Griffin Podcast 9:34 – Why no HVAC businesses if it’s such an attractive sector 13:56 – thoughts on rolling up similar businesses and horizontal scale 16:04 – Another industry Brent would focus on 18:02 – Difference between property management in larger cities vs smaller metro areas 18:51 – What role does profit margin play when Brent is evaluating a business 22:46 – The appeal of a hyper cyclical business             22:52 – Brent Beshore Podcast Episode 27:27 – Favorite counter cyclical business 28:14 – How they judge assets, tangible vs intangible assets 33:58 – How does he think about wage inflation when considering the cost of a business 37:21 – His fascination with pet crematoriums 38:57 – History of the permanent equity fund and the changes by having a larger pool of capital 43:48 – Pitching investors on a new structure for the business 46:14 – How will this business model scale Learn More For more episodes go to InvestorFieldGuide.com/podcast.  Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub Follow Patrick on twitter at @patrick_oshag

with @francescagino and @omnivorousread In this episode of the a16z Podcast, Harvard Business School Professor Francesca Gino, a social scientist who studies organizations, breaks down what makes rebels different in how they tend to see and do things—whether that’s cooking, flying planes, or holding board meetings—and what we can all learn from “rebel talent” to make our organizations more productive and innovative.

Lex Fridman is a research scientist at MIT working on human-centered artificial intelligence and autonomous vehicles. Check out is podcast "Artificial Intelligence Podcast" available on Spotify. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Jim Norton is a stand-up comedian, radio personality, author, and actor. Check out his podcast the “Chip Chipperson Podacast" available on Spotify. Look for Jim on "The Degenerates - Season 2" now streaming on Netflix. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Black history taught in US schools is often watered-down, riddled with inaccuracies and stripped of its context and rich, full-bodied historical figures. Equipped with the real story of Rosa Parks, professor David Ikard highlights how making the realities of race more benign and digestible harms us all -- and emphasizes the power and importance of historical accuracy. Hosted on Acast. See acast.com/privacy for more information.