Is there a limit to what humans can do? And if so, how do you know when you've reached it? Welcome to part one of a two-part series on human performance with professional rock climber Alex Honnold.

@vijaypande reads out loud on why we shouldn't fear AI in healthcare/ medicine

@conniechan reads out loud on the case of WeChat and mobile in China

@astrange reads out loud on why every company is (or will be) a fintech company

continuing our series of a16z posts, read out loud by their authors here

With @jorgecondebio @vijaypande and @lr_bio On this special holiday weekend edition of the a16z bio Journal Club we discuss a recent opinion article suggesting the end of Eroom’s Law—the decades long trend in biopharma R&D towards higher and higher costs per new drug—and our take on the big trends in this space.

With @trvrb @heyjudka and @lr_bio We speak with Trevor Bedford, Associate Professor at the Fred Hutchinson Cancer Research Center, about a wide-range of topics, including changes in scientific communication and publishing spurred by the COVID-19 pandemic, the power of genomic epidemiology for tracking the evolution of outbreaks, how this information can aid public health decisions, and preparing for and preventing the next pandemic.

with @justin_larkinMD and @lr_bio The FDA recently approved the first prescription video game. The a16z bio Journal Club covers one of the key clinical trials that supported this FDA decision and discusses the evidence showing that this game can have a measurable impact on the attention impairments seen in children with ADHD.

Gross margins are one of the most important financial metrics for any startup, but figuring out what does and doesn't go into them as a company grows is not as simple as it sounds. In this episode, we discuss why and when margins matter, and how they evolve along the way.

Superhuman Founder Rahul Vohra and a16z General Partner David Ulevitch discuss how to build a product that can turn any user into a power user.

with @heyjudka and @lr_bio a16z bio Journal Club covers recent research building artificial chloroplasts to improve the processes of photosynthesis and carbon fixation, and how these artificial chloroplasts could one day be used to improve crop growth and carbon sequestration in plants.

This episode is the second in a two-part series that examines the pandemic’s impact on real estate. This episode, Part 2, focuses on the fallout for renters and landlords.

This episode is the first in a two-part series that examines the pandemic’s impact on real estate. Part 1 focuses on prospective home buyers, sellers, and existing homeowners. Part 2 (streaming on 6/17) addresses renters and landlords. How has social distancing shaken up the market to buy? What’s the ripple effect of eviction freezes and a record number of homes in forbearance? And how can tech streamline the inefficient process of renting, buying, and selling a home?

with @vijaypande, @drGregBowman, @lr_bio This episode celebrates the 20th anniversary of Folding at Home, the distributed computing project for simulating protein dynamics. Folding at Home is run on millions of devices, is the world’s largest supercomputer, and tackles some of biology’s toughest problems, including COVID-19.

with @sacjai, @vjkedar, @julesyoo, @omnivorousread The way we deliver healthcare has changed enormously over the last century, shifting from house calls by doctors to your own to institutionalized settings like hospitals and clinics. But now that trend has started to shift again, as some of the care we get in the hospitals and clinics has been "unbundled" back towards home settings for chronically ill patients or seniors. And now, of course, the impact of COVID-19 has created a huge sudden demand for home-based care, as all of us try to figure out how to manage certain healthcare needs at home. So, is home-based healthcare better? And what do we truly need to deliver the best care to patients, in their own homes? What do we gain and lose in different care delivery settings, and what shifts of mindset and new logistical processes do we need now, to best accomplish unbundling healthcare into the home? In this conversation, Vijay Kedar, CEO and cofounder of Tomorrow Health, a tech platform that delivers the products and services needed for home-based care; Sachin Jain, physician, previous CEO of Caremore and Aspire Health; part of the founding team at CMMI, the Centers of Medicare and Medicaid Innovation, now incoming CEO of The Scan Group and Healthplan; and a16z General Partner Julie Yoo join a16z's Hanne Tidnam in conversation to talk about where we are today and where we are going in home-based healthcare.

with @DrIvorHorn, @jeffkaditz, @julesyoo, @omnivorousread Primary care was meant to be the front door to the healthcare system, but in some ways never set up for success to begin with. We need a new operating system for primary care—one with a different, deeper understanding of the patient, the context of their world around them, and the processes we have in place to figure out who sees a doctor and when, in order to use the healthcare system most efficiently. In this episode of the a16z Podcast, we talk about what the primary care of the future should actually look like and new ways we can understand what patients and doctors truly need, when. Joining us for the conversation are General Partner Julie Yoo, physician entrepreneur Ivor Horn, a primary care pediatrician for more than 20 years, and Jeff Kaditz, CEO and founder of Q.bio, a platform that identifies and monitors each individual’s biggest health risks.

with @mmasnick and @smc90 What does (and doesn’t) this section of the Communications Decency Act really say; common myths and misconceptions; and much more on this recent episode of our show 16 Minutes, where we cover headlines and tech trends -- offering analysis, frameworks, explainers, and more: a16z.com/16minutes

with terrybrown @shakasenghor @bhorowitz Given recent events around George Floyd and far beyond, this special episode of the a16z Podcast features Shaka Senghor, a leading advocate for criminal justice reform, and Terry Brown, a former police officer in East Palo Alto -- who, incidentally, both grew up in Detroit but ended up on different sides of the law -- in conversation with a16z co-founder Ben Horowitz. The conversation goes deep and on the ground...

It's easier to move upmarket than down. We look at why this gives SaaS startups the advantage against incumbents and how to price for the move.

Today’s episode is about a practical application of crypto — namely, the way it can “tokenize” fandom. More broadly, it’s about fan engagement, and the increasingly blurred lines between sports, culture and tech.  We talked to NBA player Spencer Dinwiddie, of the Brooklyn Nets. Spencer created a new platform on the crypto blockchain Ethereum that gives fans the opportunity to invest directly in his revenue-generating potential, through debt securities.  Joining this conversation are a16z managing partner and tech investor Jeff Jordan, who has long followed the evolving relationship between sports and tech. Also joining is Jesse Walden, a former a16z crypto partner and co-founder of Mediachain. He’s also a former music promoter and manager whose focus was on helping artists stay independent.   We discuss the evolution of models for fan engagement; how social media has changed the game; and where technologies like cryptonetworks and blockchains come in.