What if the biggest challenge of our time isn’t living longer, but living better? In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finance, career planning, and even our cultural perceptions of aging—need a fundamental overhaul. We’re joined by Dr. Andrew Scott, author of The Longevity Imperative, and Vijay Pande a16z’s Bio & Health general partner, to explore how a shift from “sick care” to “health care” could transform our lives. Together, we discuss the implications of longer lifespans, from the individual choices that can improve our healthspans to the economic and societal shifts required to sustain a healthier, more productive aging society. Join us as we reimagine the future of aging, where living to 100 can be more than survival—it can be a life well-lived.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace. In this episode, we discuss the overlooked crisis of American manufacturing and what it means for our national resilience. a16z’s Oliver Hsu hosts a conversation with founders Jordan Black (Senra Systems), Chris Power (Hadrian), and Bryon Hargis (Castelion) on why we need to revive our industrial base — and fast. From outdated regulations to the adoption of automation, they break down the “death by a thousand paper cuts” that has left our production capabilities lagging behind. Yet, it’s not all grim: these founders share how their companies are taking bold, vertically integrated approaches to reinvent the sector and reclaim America's industrial edge.

2024 has been a milestone year for autonomous tech. Waymo’s fully autonomous driver has surpassed 20 million miles, while FAA approvals now allow commercial drones to fly without visual observers, advancing air autonomy in unprecedented ways. In this special live recording from SF Tech Week, a16z partner Erin Price-Wright moderates a panel of experts from three key domains—air, land, and sea—to explore the latest real-world deployments of autonomous systems, the impact of new chips on cost and efficiency, building full-stack solutions, managing risk, and the evolving role of regulation in driving these technologies forward. Joining the conversation is Macario Namie, CMO of Skydio, discussing the transition from consumer drones to enterprise and government use; Vijay Patnaik, Head of Product at Applied Intuition, who shares insights on developer tools and software for autonomous vehicles; and Peter Bowman-Davis, engineering fellow at a16z, diving into maritime autonomy based on his work at Saronic.

We take you behind the scenes of our newly released, annual State of Crypto Report — a16z crypto's analysis of the latest data and trends that have defined the industry in 2024. This year's report features some brand new insights, from estimating the number of real crypto users globally, to understanding how much interest in crypto swing states may have ahead of the U.S. election. We also dig into infrastructure improvements to blockchains and key applications — including stablecoins, AI, and so-called DePIN. Be sure to visit a16zcrypto.com for all this and more including a new “Builder Energy” dashboard, which we’ll discuss on the show.

What does Rich Sutton’s "Bitter Lesson" reveal about the decisions Tesla is making in its pursuit of autonomy? In this episode, we dive into Tesla’s recent "We, Robot" event, where they unveiled bold plans for the unsupervised full-self-driving Cybercab, Robovan, and Optimus—their humanoid robot, which Elon Musk predicts could become “the biggest product ever.” Joined by a16z partners Anjney Midha and Erin Price-Wright, we explore how these announcements reflect the evolving intersection of hardware and software. We’ll unpack the layers of the autonomy stack, the sources of data powering it, and the challenges involved in making these technologies a reality. Anjney, with his experience in computer vision and multiplayer tech at Ubiquity6, and Erin, an AI expert focused on the physical world, share their unique perspectives on how these advancements could extend far beyond the consumer market.

In 2024, marking 10 years since its launch, Apple Pay now boasts hundreds of millions of consumers in 78 markets, at checkout on millions of websites and apps, in tens of millions of stores worldwide, and is supported by more than 11,000 bank and network partners. In this episode, a16z General Partner Alex Rampell sits down with Jennifer Bailey, VP of Apple Pay and Apple Wallet, to explore how Apple has transformed digital payments. Jennifer reveals how Apple Pay and Apple Wallet have grown beyond payments to include transit cards, car keys, and more. They also discuss the challenges of driving adoption, the future of digital wallets, and Jennifer’s insights for entrepreneurs.

Lisa Su has transformed AMD into a global leader in AI and high-performance computing. In this episode of the AI Revolution (AIR) series , Bob Swan, a16z Operating Partner and former CEO of Intel, sits down with Lisa Su, CEO of AMD, to discuss how her leadership has propelled AMD’s growth and positioned the company at the forefront of AI innovation. They explore AMD’s pivotal role in democratizing the benefits of gen AI, the evolution of AI computing, and the importance of open ecosystems and partnerships in driving technological breakthroughs.

Deepfakes—AI-generated fake videos and voices—have become a widespread concern across politics, social media, and more. As they become easier to create, the threat grows. But so do the tools to detect them. In this episode, Vijay Balasubramaniyan, cofounder and CEO of Pindrop, joins a16z’s Martin Casado to discuss how deepfakes work, how easily they can be made, and what defenses we have. They’ll also explore the role of policy and regulation in this rapidly changing space. Have we lost control of the truth? Listen to find out.

Last week was another big week in technology. Google’s NotebookLM introduced its Audio Overview feature, enabling users to create customizable podcasts in over 35 languages. OpenAI followed with their real-time speech-to-speech API, making voice integration easier for developers, while Pika’s 1.5 model made waves in the AI world. In this episode, we chat with the a16z Consumer team—Anish Acharya, Olivia Moore, and Bryan Kim—about the rise of voice technology, the latest AI breakthroughs, and what it takes to capture attention in 2024. Anish shares why he believes this could finally be the year of voice tech.

In 1995, just 2% of couples met online. Today, that number has surged to over 50%, making online dating the top way couples connect. In this episode, a16z General Partner Andrew Chen chats with Tinder founder Sean Rad about how he built an app that changed culture. Sean shares why seamless experiences matter, how startups often get marketing wrong, and how Tinder became the catalyst for online dating's explosive growth.

What if the key to unlocking AI's full potential lies not just in algorithms or compute, but in data? In this episode, a16z General Partner David George sits down with Alex Wang, founder and CEO of Scale AI, to discuss the crucial role of "frontier data" in advancing artificial intelligence. From fueling breakthroughs with complex datasets to navigating the challenges of scaling AI models, Alex shares his insights on the current state of the industry and his forecast on the road to AGI.

Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, our guests have long been laying the groundwork for innovations that are transforming industries today. In this episode, a16z General Partner Martin Casado joins Fei-Fei and Justin to explore the journey from early AI winters to the rise of deep learning and the rapid expansion of multimodal AI. From foundational advancements like ImageNet to the cutting-edge realm of spatial intelligence, Fei-Fei and Justin share the breakthroughs that have shaped the AI landscape and reveal what's next for innovation at World Labs. If you're curious about how AI is evolving beyond language models and into a new realm of 3D, generative worlds, this episode is a must-listen.

This week in consumer tech: Apple’s big reveals, OpenAI’s multi-step reasoning, and Adobe Firefly’s video model. Olivia Moore and Justine Moore, Partners on the a16z Consumer team, break down the latest announcements and how these product launches will shape the tech ecosystem, transform AI-powered experiences, and impact startups competing for attention in a fast-moving market.

Vijay Pande, founding general partner, and Julie Yoo, general partner at a16z Bio + Health, come together to discuss the grand challenges facing healthcare AI today. The talk through the implications of AI integration in healthcare workflows, AI as a potential catalyst for value-based care, and the opportunity for innovation in clinical trials. They also talk about the AI startup they each wish would walk through the door.

Who gets to decide what, for whom? Governance is one of the trickiest challenges people have faced, from ancient city-states to AI startups. Experts Noah Feldman, constitutional law scholar at Harvard who architected the Meta oversight board and has written multiple books, and Andrew Hall, professor of political science at Stanford and consultant to a16z crypto research, join a16z crypto editor Robert Hackett for a hallway-style conversation touring the field’s big ideas, lessons learned in practice, and the most exciting experiments happening today. They discuss everything from the history of democracy, to the dynamics (and dysfunctions) of corporate and university boards, to the hopes for blockchain-based DAOs and beyond, as well as examples of governance from big companies like Meta to startups like Anthropic, and much more.

Half of prescribed medications are never taken, and 88% of Americans are metabolically unhealthy. Despite spending 20% of our GDP on healthcare—twice that of any other developed nation—our outcomes still lag behind. In this episode, we explore why technologists must step into the healthcare ring. Solving medicine isn’t enough; we need to make healthcare a consumer-focused industry. a16z’s Vijay Pandey and Daisy Wolf discuss the rise of tech founders in healthcare, the potential of AI to transform patient care, and how this shift could lead to the next trillion-dollar company. Can tech truly disrupt this complex, regulated industry?

Latin America is emerging as a tech powerhouse, but it's not a one-size-fits-all market. In this episode, we explore why what works in Argentina won’t necessarily fly in Brazil or Mexico, and how companies are adapting to these unique regional dynamics. Join Dileep Thazhmon, Cofounder and CEO of Jeeves; Santiago Suarez, Cofounder and CEO of Addi; Gabriel Vasquez, a16z investment partner; and Angela Strange, a16z General Partner, as they discuss the future of fintech in LatAm and the unique approach required to succeed in this diverse market. ​​Whether you're interested in the nuances of product development, the complexities of scaling across diverse markets, or the future of fintech in Latin America, this episode offers perspectives from industry leaders deeply invested in the region's tech ecosystem who believe the next big tech giants might just come from Latin America.

In this episode, we cover the recent data breach of nearly 3B records, including a significant number of social security numbers. Joining us to discuss are security experts Joel de la Garza and Naftali Harris. Incredibly enough, Naftali and his team were able to get their hands on the breached dataset and were able to validate the nature of the claims. Listen in as we explore the who, what, when, where, why… but also how a breach of this magnitude happens and what we can do about it.

This episode from Web3 with a16z Crypto, is all about innovation on a global scale, exploring both ecosystem and individual talent levels. We examine what works and what doesn’t, how certain regions evolve into startup hubs and economic powerhouses, and what constitutes entrepreneurial talent. We also discuss the nature of ambition, the journey to finding one’s path, and broader mindsets for navigating risk, reward, and dynamism across various regions, with a particular focus on London and Europe. Joining us is Matt Clifford, who played a pivotal role in the London entrepreneurial and tech ecosystem since 2011, is the Chair of Entrepreneur First and the UK’s Advanced Research and Invention Agency (ARIA). Before this episode was recorded, Matt served as the Prime Minister’s representative for the AI Safety Summit at Bletchley Park. Recently, he was appointed by the UK Secretary of Science to deliver an “AI Opportunities Action Plan” to the UK government. This episode was recorded live from Andreessen Horowitz’s first international office in London. For more on our efforts and additional content, visit a16zcrypto.com/uk.

Once criticized for lacking ambition, French founders are now aiming to create the world’s largest companies. With a thriving ecosystem attracting talent from across Europe and the US, France is becoming a major player on the global stage. In this episode, we cover the unique advantages of building startups in France. Roxanne Varza, Director of Station F; Antoine Martin, co-founder of Amo and Zenly; and Brian Kim, a16z consumer partner, discuss the key factors driving this transformation, including infrastructure, community, and government support. Discover how international talent, a supportive community, and robust governmental backing are propelling France’s startup scene. This episode is filled with insights into why France is now an exciting place to build a startup.