🇺🇸 United States Episodes

In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.  In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Dr. David Sinclair, Harvard Medical School   00:03:45 Sponsors: AG1, LMNT & Waking Up 00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging   00:10:23 What Causes Aging? The Epigenome   00:15:53 Cosmetic Aging   00:17:15 Development Never Stops, Horvath Clock   00:20:12 Puberty Rate as a Determinant of Aging Rate   00:23:00 Fasting, Hunger & Food Choices   00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy   00:34:50 Caffeine, Electrolytes   00:35:56 Blood Glucose & the Sirtuins; mTOR   00:37:55 Amino Acids: Leucine, “Pulsing”   00:44:35 Metformin, Berberine   00:50:29 Resveratrol, Wine   00:53:20 What Breaks a Fast?   00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing   01:09:10 Are Artificial Sweeteners Bad for Us?   01:12:04 Iron Load & Aging   01:15:05 Blood Work Analysis   01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary   01:26:02 Amino Acids, Plants, Antioxidants   01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen   01:40:35 Neuroplasticity & Neural Repair   01:46:19 Ice Baths, Cold Showers, “Metabolic Winter”   01:48:07 Obesity & How It Accelerates Aging, GnRH   01:52:10 Methylation, Methylene Blue, Cigarettes   01:56:17 X-Rays   01:59:00 Public Science Education, Personal Health   02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com   02:08:13 Zero-Cost Support & Resources, Sponsors, Supplements, Instagram   Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

We dive into trash bags with Woody Harrelson, who comes to us live from Winnipeg. We explore Woody’s life and career, we get our first ‘random listener’ question, and Will discusses that time he couldn’t find the mousse. See you at LAX!

Leo Kearse is a comedian, writer and a YouTuber. I brought Leo on to discuss the most important news stories of the last few weeks. Real hard hitting stuff today like why JK Rowling has been written out of the new Fantastic Beasts trailer, how Sainsbury's are signalling their virtue by telling shoppers that they're racist on Twitter, why Jessie from Little Mix has been accused of appropriating black culture because she has ginger curly hair, how Nicki Minaj is rehabilitating people's personal brands over Instagram Live, why Leo got involved in a debate about censorship in comedy which descended into the historic oppression of women's football and much more... Sponsors: Join the Modern Wisdom Community to connect with me & other listeners - https://modernwisdom.locals.com/ Get 5 days unlimited access to Shortform for free at https://www.shortform.com/modernwisdom (discount automatically applied) Get a Free Sample Pack of all LMNT Flavours at https://www.drinklmnt.com/modernwisdom (discount automatically applied) Extra Stuff: Subscribe to Leo's YouTube Channel - https://www.youtube.com/channel/UCp1hRBGoDHKSn4HiHIzkXAw Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/  Learn more about your ad choices. Visit megaphone.fm/adchoices

Also: Angela proposes an upgrade to the show.

Ray Dalio is an investor, author, and founder of Bridgewater Associates. Please support this podcast by checking out our sponsors: – Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil – GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k – Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off – Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium – MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Ray’s Twitter: https://twitter.com/RayDalio Ray’s Instagram: https://www.instagram.com/raydalio Books & resources mentioned: Ray’s books: https://amzn.to/3swN5uw Ray’s free personality test: https://principlesyou.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/lexfridman – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (08:14) – Money or power (11:50) – Big Cycle (31:43) – Collapse of the American Empire (40:10) – War (43:18) – Xi Jinping (49:21) – Importance of freedoms (55:24) – Democracy’s vulnerability (58:49) – Communism’s vulnerability (1:05:50) – Vladimir Putin (1:09:55) – Understanding China (1:17:23) – Henry Kissinger (1:27:44) – Elon Musk and Dogecoin (1:29:41) – How to take notes (1:33:24) – Advice for young people (1:37:30) – Hope for humanity

Brian Redban is a comedian and the founder of the Deathsquad podcast network.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this stunning spoken-word performance, poet and "freedom-forging futurist" Naima Penniman celebrates the wonders of the natural world and humanity's connection to it. "I wonder if the sun debates dawn some mornings," she says.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

Tim Dillon is a stand up comedian and CEO of Fake Business. His podcast “The Tim Dillon Show” is available on Spotify. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Peter Wang is the co-founder & CEO of Anaconda and one of the most impactful leaders and developers in the Python community. Also, he is a physicist and philosopher. Please support this podcast by checking out our sponsors: – Quip: https://getquip.com/lex to get first refill free – Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off – GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k – Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off – BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Peter’s Twitter: https://twitter.com/pwang Anaconda’s Website: https://www.anaconda.com/ Books & resources mentioned: Zen and the Art of Motorcycle Maintenance (book): https://amzn.to/3EnCELK Lila (book): https://amzn.to/30VKIpE PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/lexfridman – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (06:49) – Python (10:20) – Programming language design (30:22) – Virtuality (40:22) – Human layers (47:21) – Life (52:45) – Origin of ideas (55:17) – Eric Weinstein (1:00:16) – Human source code (1:04:13) – Love (1:18:32) – AI (1:31:55) – Meaning crisis (1:54:28) – Travis Oliphant (2:00:53) – Python continued (2:30:36) – Best setup (2:37:54) – Advice for the youth (2:46:28) – Meaning of Life

(0:00) Catching up on the Web3 wars and Jack Dorsey sounding off (5:10) Biggest Winner - Politics (9:43) Biggest Loser - Politics (14:37) Biggest Political Surprise (22:24) Biggest Winner - Business (26:03) Biggest Loser - Business (30:54) Biggest Business Surprise (35:27) Best Science Breakthrough (42:56) Biggest Flash in the Pan (47:08) Best CEO (52:43) Best Investor (57:12) Best Turnaround (1:02:47) Worth Human Being (1:07:31) Best Meme (1:10:02) Most Loathsome Company (1:14:47) Best New Tech (1:20:22) Best Trend (1:22:17) Worst Trend (1:26:02) Favorite Media (1:34:15) The Rudy Giuliani Award for Self-Immolation (1:39:07) The Besties spread holiday cheer with each other Follow the besties: https://twitter.com/chamath https://linktr.ee/calacanis https://twitter.com/DavidSacks https://twitter.com/friedberg Follow the pod: https://twitter.com/theallinpod https://linktr.ee/allinpodcast Intro Music Credit: https://rb.gy/tppkzl https://twitter.com/yung_spielburg Intro Video Credit: https://twitter.com/TheZachEffect Referenced in the show: https://twitter.com/jack https://twitter.com/Jason/status/1473321415285751811 https://twitter.com/cdixon/status/1473150192400486401 https://twitter.com/jack/status/1473155226194616325 https://twitter.com/elonmusk/status/1472754632325795843 https://www.theinformation.com/articles/coinbase-enters-the-metaverse-an-exodus-from-meta-s-novi-unit?rc=g3wfdp https://dune.xyz/rchen8/opensea https://phys.org/news/2021-09-chinese-scientists-starch-synthesis-carbon.html https://www.bbc.com/news/science-environment-55564448 https://www.amazon.com/Gray-Lady-Winked-Misreporting-Fabrications/dp/1736703315 https://www.wsj.com/articles/washington-post-grasps-for-new-direction-as-trump-era-boom-fades-11639695007 https://twitter.com/GavinSBaker/status/1473326791293128706 https://scitechdaily.com/fusion-breakthrough-at-the-brink-of-fusion-ignition-at-national-ignition-facility https://www.amazon.com/Grinding-It-Out-audiobook/dp/B07H4WXR4N https://www.amazon.com/Changing-World-Order-Nations-Succeed/dp/1982160276 https://www.amazon.com/San-Fransicko-Progressives-Ruin-Cities/dp/0063093626 https://www.amazon.com/Wanting-Power-Mimetic-Desire-Everyday/dp/1250262488

Brian Simpson is a standup comedian and host of the podcast "BS with Brian Simpson." He's also on Season 3 of The Standups on Netflix premiering on Decemeber 29. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Without the internet, how would you have coped with the pandemic -- from work and school, to maintaining your closest relationships? In the digital age, reliance on the internet is so common and seems ubiquitous, yet billions of people worldwide still go without it. Digital transformation strategist Priscilla Chomba-Kinywa advocates for collective access to the opportunities and potential the internet provides, underscoring the necessity of free and fair digital rights for all.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

Sam Parr (@theSamParr) sits down with Steph Smith (@StephSmithio), indie creator and host of the "Sh*t You Didn't Learn in School" podcast, to talk about Tyler Perry and how he was able to become a billionaire in the entertainment industry.  _____ * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. * Would you like to participate in our clips contest? Earn up to $10k by remixing My First Million episodes. To learn more, go to mfmpod.com/clips. * Want more insights like MFM? Check out Shaan's newsletter.

Sam Parr (@theSamParr) sits down with Steph Smith (@StephSmithio), indie creator and host of the "Sh*t You Didn't Learn in School" podcast, to talk about companies with only one employee that are making millions and what we can learn from them.  _____ * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. * Would you like to participate in our clips contest? Earn up to $10k by remixing My First Million episodes. To learn more, go to mfmpod.com/clips. * Want more insights like MFM? Check out Shaan's newsletter. _____ Show Notes: (00:50) - How Steph plans to become a billionaire (04:30) - BuiltWith.com, Levels.io, and Ugmonk. (08:00) - Carrd. About.me. Unfold. Media kits. (11:30) - NextEpisode.net (18:30) - The MotoMeter (22:15) - HeadLime (26:00) - Sites that have a surprising amount of traffic - GlitchnDealz.com, FoodTimeline.org (40:30) - "Your listicle is my opportunity" (45:15) - Magnus Carlsen and chess

My guest today is Nick Saltarelli, co-founder of the functional chocolate bar business, Mid-Day Squares. Nick started the company with his wife and brother-in-law a few years ago to build on a simple idea: if the big chocolate bar brands were to start today, what would they look like?   In our conversation, we discuss the importance of Mid-Day Squares’ $100 million revenue target, what’s wrong with the CPG industry today, and how to keep a long-term mindset while making the most of every day. Please enjoy this unique conversation with Nick Saltarelli.   For the full show notes, transcript, and links to mentioned content, check out the episode page here.   -----   This episode is brought to you by Pilot. Pilot handles your startup’s finance, accounting, and tax prep needs, so you can focus on what matters most—building your business. Join over 1,000 startups that rely on Pilot to help them scale. Founder’s Field Guide listeners get 20% off their first six months. Get in touch with Pilot at https://pilot.com/founders.    -----   Founder's Field Guide is a property of Colossus, LLC. For more episodes of Founder's Field Guide, visit joincolossus.com/episodes.   Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here.   Follow us on Twitter: @patrick_oshag | @JoinColossus   Show Notes [00:02:01] - [First question] - What Mid-Day Squares is and how he started the business [00:04:48] - Why they’re so publicly open about their company’s goals [00:09:05] - Major lessons he learned from his father’s early passing and being around very successful entrepreneurs at a young age  [00:16:51] - What long term thinking unlocks for him in short term progress [00:21:05] - Becoming unexpectedly close and learning from Rory Olson  [00:25:44] - What Rory taught him about deal-making [00:28:35] - Lessons from Rory about raising capital [00:33:25] - Opportunities in a seemingly oversaturated market like chocolate [00:42:46] - An example of doing something contrarian that worked out [00:47:11] - Their unique approach to marketing Mid-Day Squares [00:57:33] - Lessons learned about building a manufacturing operation after years in China [01:02:35] - What we can expect from Mid-Day Squares in the near future [01:06:59] - The kindest thing anyone has ever done for him [01:08:05] - Mid-Day Squares Uncensored Podcast

Aaron Alexander is a manual therapist and movement coach, founder of the Align Method and an author. Health & fitness has been broken down into a very compartmentalised, reductionist view. Muscles are trained in isolation, mindfulness practise doesn't occur in the gym, physicality isn't thought of when you sit down at your desk. I wanted to speak to Aaron to explain how we can take a global, aligned, macro-view of our body's wellness to impact more than just how we look but how we feel, think, sit, sleep, have sex and everything else... Sponsors: Join the Modern Wisdom Community to connect with me & other listeners - https://modernwisdom.locals.com/ Get 83% discount & 3 months free from Surfshark VPN at https://surfshark.deals/MODERNWISDOM (use code MODERNWISDOM) Get 5 days unlimited access to Shortform for free at https://www.shortform.com/modernwisdom (discount automatically applied) Get 20% discount on the highest quality CBD Products from Pure Sport at https://bit.ly/cbdwisdom (use code: MW20) Extra Stuff: Check out Aaron's website - https://www.alignpodcast.com/ Watch Aaron's Podcast - https://www.youtube.com/alignpodcast    Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/  Learn more about your ad choices. Visit megaphone.fm/adchoices

Ari Shaffir is the host of "The Skeptic Tank." His most recent special, "Ari Shaffir: Double Negative," is available via Netflix. Tony Hinchcliffe is a stand-up comedian, writer, and actor. He's also the co-host, along with Brian Redban, of the podcast and live YouTube show Kill Tony. Learn more about your ad choices. Visit podcastchoices.com/adchoices

As chairman of the world's largest maritime shipping company, Jim Hagemann Snabe thinks a lot about how goods get where they need to go and the impact their journey has on the planet. Leading the effort to decarbonize shipping by 2050, he shares a plan to convert green electricity into green liquid fuel to power vessels in a process called "power-to-X" -- and urges global leaders to join the voyage towards an innovative, sustainable and fast-approaching future.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

The Best of Oprah's Super Soul | This Episode Was Originally Published on September 20th, 2017 Life changing wisdom and insights from one of America’s key spiritual voices, Sister Joan Chittister. Sister Chittister is a Roman Catholic nun and author of over 50 books. She’s a tireless advocate of justice, peace and equality, especially for women, all over the world.

Season 9 ends at the beginning — with the man who changed Hollywood forever and wrote the blueprint for A16Z’s upending of Silicon Valley a generation later, Michael Ovitz and his “Dream Factory”, Creative Artists Agency. From Jurassic Park to Ghostbusters, Back to the Future, Goodfellas, Rain Man, ER, and even the Coca-Cola polar bears... almost nothing in 80s and 90s pop culture didn’t have CAA’s stamp on it. Speaking of dreams, this episode was totally one for us, and we hope you enjoy listening to it as much as we did making it!!Sponsors:Sierra: https://bit.ly/acquiredsierraSentry: https://bit.ly/acquiredsentryAnthropic: https://bit.ly/acquiredclaude25Vanta: https://vanta.com/acquired More Acquired!Get email updates with hints on next episode and follow-ups from recent episodesJoin the SlackSubscribe to ACQ2Merch Store!© Copyright 2015-2025 ACQ, LLCLinks:Michael’s (truly excellent) book, Who Is Michael Ovitz?: https://www.amazon.com/dp/B07B2HS77M/‍Note: Acquired hosts and guests may hold assets discussed in this episode. This podcast is not investment advice, and is intended for informational and entertainment purposes only. You should do your own research and make your own independent decisions when considering any financial transactions.