🇺🇸 United States Episodes

My guest is Dr. Nirao Shah, MD, PhD, a professor of psychiatry, behavioral sciences and neurobiology at Stanford University School of Medicine. We discuss how the brains of males and females differ and how those differences arise from different genes and hormones during fetal development, in childhood and adulthood. We discuss what drives male- versus female-specific behaviors and how hormonal fluctuations across the lifespan, including puberty, the menstrual cycle, menopause and aging – affect behavior, cognition and health. Additionally, we discuss how biology relates to gender identity and the impact of hormone therapies on brain circuits that regulate mating, parenting and social bonding. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Nirao Shah 00:02:11 Mice, Humans & Brain, Biological Conservation 00:05:25 Hormones, Nature vs Nurture 00:07:13 Biological Sex Differences, Chromosomes & SRY Gene, Hormones 00:16:01 Sponsors: Maui Nui & Eight Sleep 00:19:09 Androgen Mutations, Feminization & Masculinization 00:22:04 SRY Gene; Animals & Sexual Trans-Differentiation 00:27:49 Hormones & Biological Brain Differentiation 00:31:22 Congenital Adrenal Hyperplasia, Androstenedione; Stress & Pregnancy 00:35:56 Genes, Brain Differentiation & Sexual Identity; Congenital Adrenal Hyperplasia 00:43:37 Testosterone, Estrogen & Brain Circuits 00:47:27 Sponsors: AG1 & LMNT 00:50:36 Intersex Individuals, Castration 00:52:23 Female Sexual Behavior, Brain, Testosterone & Pheromones 00:57:58 Identify as Heterosexual or Homosexual, Difference in Hormone Levels? 01:00:42 Gender, Sexual Orientation & Hormones; Hormone Replacement Therapy 01:10:21 Aromatization; Steroid Hormones & Gene Expression 01:15:00 Kids & Changing Gender Identity 01:19:05 Sexual Behavior, Refractory Period & Male Brain, Tacr1 Cells 01:21:31 Sponsor: Function 01:23:19 Hypothalamus, Dopamine, Prolactin, Cabergoline, Libido, Dopamine 01:27:05 Brain Circuits, Aggression & Sexual Behavior 01:32:40 Refractory Period; Age, Testosterone & Libido 01:36:07 Tacr1 Cells in Females, Periaqueductal Gray & Innate Behaviors 01:40:00 Parenting Behaviors & Brain Circuits; Pet Dogs 01:43:12 Oxytocin, Pair Bonding, Vasopressin; Biological Redundancy 01:47:22 Libido, Melanocortin, Tacr1 Neurons; GLP-1 Agonists, Clinical Trials; Kisspeptin 01:56:43 Female Brain Changes, Menstrual Cycle, Pregnancy, Menopause; Estrogen; Men & Hormone Fluctuation? 02:04:10 Life Experience Male vs Female, Sex Recognition, Behaviors & Context 02:16:05 Pain Management; Endocrine Disrupters, Gender Identity 02:21:03 Future Projects 02:24:29 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Are you still off sugar? It’s our friend Julia Garner. Witch energy, Waymo advocacy, pretending to be good at stuff, and feeling uncomfortable to feel comfortable. Failure is a friend of the clown… on an all-new SmartLess.

Rory Sutherland is one of the world’s leading consumer behaviour experts, the Vice Chairman of Ogilvy Advertising and an author. The world is evolving at an unprecedented pace. With the rise of AI, we're witnessing a collision between the old world and the new. As technology advances, the question becomes: how can innovation repair outdated systems and shape the future in marketing and beyond? Expect to learn about Rory’s first experience to Buccee’s, what Rory’s thoughts are on Waymo, Autonomous driving and the current experience of going through airports, what are some unknown gems in the UK to visit that no one knows about, how Rory would improve food delivery apps, the future of AI in marketing and AI wearables, Rory’s advice for what people should do to optimise for attention, and much more… Sponsors: See me on tour in America: ⁠https://chriswilliamson.live⁠ See discounts for all the products I use and recommend: https://chriswillx.com/deals Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get a 20% discount on Nomatic’s amazing luggage at https://nomatic.com/modernwisdom Get a Free Sample Pack of LMNT’s most popular Flavours with your first purchase at https://drinklmnt.com/modernwisdom Get the best bloodwork analysis in America at https://functionhealth.com/modernwisdom Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: https://tinyurl.com/43hv6y59 #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: https://tinyurl.com/2rtz7avf #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: https://tinyurl.com/3ccn5vkp - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices

What is it about them, our mean friends? They treat us poorly, they don't call us back, they cancel plans at the last minute, and yet we keep coming back for more. Popular bullies exist in business, politics — everywhere. How do they stay so popular? Visit thisamericanlife.org/lifepartners to sign up for our premium subscription.Prologue: We hear kids recorded at Chicago's Navy Pier and at a public swimming pool discussing their mean friends. And Ira Glass interviews Lillie Allison, 15, about the pretty, popular girls who were her best friends—until they cast her out. (5 minutes)Act One: Jonathan Goldstein interrogates the girls, now grown up, who terrorized him and his classmates years ago in school—and finds they can be just as scary as ever. (18 minutes)Act Two: We conduct an experiment to test whether being nice actually pays by equipping two waitresses with hidden microphones to record their interactions. Each waitress is instructed to be super friendly with half of their tables while remaining aloof with the other half. We then compare the tips to see which approach was more profitable. (10 minutes)Act Three: A case study in every word from a friend meaning its opposite. (4 minutes)Act Four: An excerpt of Bernard Cooper's story about the bill he got from his own father, for the entire cost of his childhood. Actor Josh Hamilton reads. (19 minutes)Transcripts are available at thisamericanlife.orgThis American Life privacy policy.Learn more about sponsor message choices.

Are you feeling overwhelmed, uninspired, or burned out at work? In this special Unsolicited Advice episode, Anne and Frances are getting ready for summer by tackling the importance of rest and the power of intention. They offer unexpected tips and tricks for recovering from constant stress, owning what you need to feel alive and engaged, and creating an experience of work that unleashes your ambition. Hosted on Acast. See acast.com/privacy for more information.

De plus : où se situe la limite entre les acronymes, les sigles et le charabia ? Cet épisode a été diffusé pour la première fois le 20 décembre 2020.

How do I learn to delegate? When is it time to expand? How can I find the right partners? Hear two iconic leaders – Sarah Robb O’Hagan and Elan Lee – take on real questions from early stage founders in our Masters of Scale Strategy Session. Robb O’Hagan has led iconic brands like Gatorade, Equinox and Exos. Lee is the founder and CEO of the game company Exploding Kittens.Don’t miss our next free, virtual event on Aug 14 with Reid Hoffman and Kickstarter CEO Everette Taylor. Register now: mastersofscale.com/auguststrategysessionMasters of Scale Strategy Sessions are presented by Capital One Business.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

"You don't predict the future -- you imagine the future," says sci-fi writer Charlie Jane Anders. In a talk that's part dream, part research-based extrapolation, she takes us on a wild, speculative tour of the delights and challenges the future may hold -- and shows how dreaming up weird, futuristic possibilities empowers us to construct a better tomorrow.This episode originally aired October 14, 2022. Hosted on Acast. See acast.com/privacy for more information.

I hit 3.7 million Subscribers on YouTube!! To celebrate, I asked for questions from YouTube, X, and Instagram, so here’s another 90 minutes of me trying to answer as many as possible. Expect to learn all about my new hairstyle, how to best deal with procrastination, which people are up next on my "Mount Rushmore" of podcast guests, what the current state of my health is, the best tips to manage stress, when podcast merch will be coming to a closet near you, which future music guests I want on the pod, the real power of money, and much more... Sponsors: See me on tour in America: ⁠https://chriswilliamson.live⁠ See discounts for all the products I use and recommend: https://chriswillx.com/deals Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get 10% discount on all Gymshark’s products at https://gym.sh/modernwisdom (use code MODERNWISDOM10) Get the brand new Whoop 5.0 at https://join.whoop.com/modernwisdom Timestamps: (0:00) - Go See Chris Live (1:19) - What’s Up with the Curly Hair? (3:28) - How To Deal with Procrastination (5:39) - Chris’ Go-To Shorts (6:58) - Future Musical Guests (8:09) - Why Won’t She Commit? (11:42) - Who’s in the Next ‘Infinity Gauntlet’? (13:34) - Will James Sexton and Sadia Khan Be Back? (13:56) - The Impact of the Male Sedation Hypothesis on Masculinity (18:15) - Chris’ Medical Updates (23:53) - The Negative Effects of Reality Shows (28:47) - How Money Can Change Your Life (32:49) - Top Tips on Stress Management (36:36) - Where Will We Be in 10 Years? (42:30) - Is Chris a Deano? (44:04) - Cool Kids Names (45:05) - How to Get Over Ghosting (49:17) - Modern Wisdom Merch (50:20) - A Love Life Catch-22 (56:58) - Dating in Your 30s (01:00:24) - How the Modern Wisdom Team was Built (01:02:19) - Are 20-Year-Olds Still Partying? (01:04:39) - The Art of Drifting (01:05:50) - How to Tackle Regret (01:07:53) - Reading List (01:09:38) - Being Loved for Being Your Authentic Self (01:14:37) - The Benefits of Having Siblings (01:16:07) - Thoughts on Travelling Alone (01:17:06) - The Rise of Hybrid Athletes (01:18:26) - Don’t Ruin Your Phone with a Phonecase (01:19:15) - Comfort Over Style (01:21:35) - Settling Down (01:24:28) - Being Roasted by Fin Taylor (01:25:20) - Seeing Sleep Token (01:25:49) - Tips on Tinnitus (01:27:18) - Would Chris Beat Lex Fridman? (01:27:28) - Outro Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: https://tinyurl.com/43hv6y59 #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: https://tinyurl.com/2rtz7avf #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: https://tinyurl.com/3ccn5vkp - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices

LIVE SHOW ALERT: August 18th, NYC. Get your tickets here. When news broke that a Japanese company, Nippon Steel, was buying the storied American steel company U.S. Steel, it was still 2023, just before an election. And right away, politicians from both sides of the aisle came out forcefully against the deal, saying the company should remain American. Before leaving office, President Biden even blocked the sale. But in a dramatic twist a few weeks ago, President Trump approved it. With a caveat: the U.S. would get what Trump called 'a golden share' in U.S. Steel.On our latest show: what even is a "golden share"? When has it been used before, and why? And, could deals like this be a good way to get foreign investment in American manufacturing...or is it government overreach? Related episodes:- When Uncle Sam owned banks and factories- How Big Steel in the U.S. fellThis episode was produced by Willa Rubin and edited by Marianne McCune. Research help from Emily Crawford and Emma Peaslee. It was fact-checked by Sierra Juarez and engineered by Robert Rodriguez. Alex Goldmark is our executive producer.Support Planet Money, get bonus episodes, sponsor-free listening and now Summer School episodes one week early by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.Listen free at these links: Apple Podcasts, Spotify, the NPR app or anywhere you get podcasts.Find more Planet Money: Facebook / Instagram / TikTok / Our weekly Newsletter.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Last week, CBS cancelled “The Late Show with Stephen Colbert.” The network said that ending the show was “purely a financial decision.” Over the years, late-night audiences and profits have dwindled. But some fans have suggested the move was partly political: CBS pulled the plug just days after Colbert criticized Paramount, CBS’s parent company, for agreeing to settle a lawsuit with President Trump for $16 million. WSJ’s Joe Flint delves into the controversy and the economics of late-night TV. Annie Minoff hosts. Further Listening: -Will Paramount Settle With Trump? -Why Buying Paramount Global Won't Be Easy  -’Love Is Blind' Is Back. Not All the Drama Is On-Screen. Sign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Mike Baker is a former CIA covert operations officer and current CEO of Portman Square Group, a global intelligence and security firm. He’s also the host of the "President’s Daily Brief" podcast: a twice daily news report on critical events happening around the globe available on all podcast platforms. https://www.portmansquaregroup.com Learn more about your ad choices. Visit podcastchoices.com/adchoices

If you want to understand how fake the current political system is, take a minute to listen to Ana Kasparian and ask yourself how much you disagree with. (00:00) Why Americans Care So Much About the Jeffrey Epstein Case (07:18) The Growing Nuance of America’s Political Parties (14:33) Why Kasparian Admitted She Was Wrong About Defunding the Police (21:32) Americans Do Not Want to Be Involved in Foreign Wars (29:48) How Radical Leftist Ideology is Destroying California (46:51) Will Tucker Ever Run for President?Ana Kasparian is a political commentator and journalist who is best known as the Executive Producer and Host of The Young Turks (TYT). While her work for TYT spans nearly two decades, Kasparian also reports for Real Clear Investigations and is a host for the popular political panel show Her Take. Kasparian's sharp analysis and outspoken views can be found across multiple outlets, including CNN, The New York Times, Newsweek, Time and more. Paid partnerships with: MeriwetherFarms: Visit https://MeriwetherFarms.com/Tucker and use code TUCKER for 15% off your first order. Eight Sleep: Get $350 off the new Pod 5 Ultra at https://EightSleep.com/Tucker Beam: Get 30% off the American Strength Bundle using the code TUCKER at https://ShopBeam.com/Tucker Learn more about your ad choices. Visit megaphone.fm/adchoices

The rapidly evolving field of protein design is revealing solutions to some of the world’s greatest problems, whether it's blocking a virus, breaking down a pollutant or creating brand-new materials. In conversation with TED’s Whitney Pennington Rodgers, biochemist David Baker explores his team’s Nobel Prize-winning work using AI to design new proteins with functions never before seen in nature — achieving breakthroughs that have fundamentally changed the future of science. (This conversation was part of an exclusive TED Membership event. TED Membership is the best way to support and engage with the big ideas you love from TED. To learn more, visit ted.com/membership.) Hosted on Acast. See acast.com/privacy for more information.

"Any historical understanding of the First Amendment would say this is just plainly unconstitutional.”

On this episode of The Ben & Marc Show, a16z co-founders Marc Andreessen and Ben Horowitz sit down with Erik Torenberg— General Partner at a16z and founder of the media company Turpentine—to unpack how the internet shattered the old media order and reshaped the way power works in America. What begins as a look at the evolution of media quickly becomes something bigger: a conversation about truth, trust, and the collapse of institutional authority. They explore how social media became both an x-ray and an engine, why authenticity now beats polish, and how the rules of politics, and journalism, have permanently changed. Together, they break down: -Why 2017 marked a structural break between tech and the press -Trump’s real training ground -The tension between objectivity, activism, and “speaking truth to power” -Why podcasters. not pundits, are setting the agenda -How the barbell strategy is reshaping media: short-form virality meets long-form depth With stops at Watergate, the rise of Rogan, the fall of legacy gatekeepers, and the media playbooks behind Obama, Trump, and the Kardashians—this episode explores how we got here, what’s next, and what it means for founders, voters, and anyone trying to build (or tell) a story.

Welcome to this classic episode. Classics are my favorite episodes from the past 10 years, published once a month. These are N of 1 conversations with N of 1 people. Brad Jacob's simple principle of "think big, move fast" is one I think about often. Brad’s resumé is remarkable. He has founded seven companies, all of which are billion-dollar or multibillion-dollar businesses. He has done 500 M&A transactions and raised $30 billion of debt and equity capital. Currently, he is the Executive Chairman of XPO, a commercial trucking company that he started in 2011 and has grown into one of the largest logistics businesses in the world. He is a true force of nature, and I hope you enjoy his episode. For the full show notes, transcript, and links to mentioned content, check out the episode page here. ----- This episode is brought to you by ⁠⁠⁠WorkOS⁠⁠⁠. WorkOS is a developer platform that enables SaaS companies to quickly add enterprise features to their applications. With a single API, developers can implement essential enterprise capabilities that typically require months of engineering work. By handling the complex infrastructure of enterprise features, WorkOS allows developers to focus on their core product while meeting the security and compliance requirements of Fortune 500 companies. Visit ⁠⁠⁠WorkOS.com⁠⁠⁠ to Transform your application into an enterprise-ready solution in minutes, not months. ----- Invest Like the Best is a property of Colossus, LLC. For more episodes of Invest Like the Best, visit ⁠⁠joincolossus.com/episodes⁠⁠.  Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up ⁠⁠here⁠⁠. Follow us on Twitter: ⁠⁠@patrick_oshag⁠⁠ | ⁠⁠@JoinColossus⁠ Show Notes (00:00:00) Welcome to Invest Like the Best (00:02:11) Identifying key factors in a market before investing (00:05:07) Gleaning insights from early acquisition experiences (00:08:43) Delving into the seller's mindset during a business sale (00:12:51) Weighing pre-built against organic growth strategies in acquisitions (00:17:20) Defining the elements of an ideal business (00:22:49) Engaging constructively with Wall Street (00:24:36) Discussing the substantial buyback of XPO shares (00:28:16) Ambition as a recurring theme in entrepreneurial success (00:30:17) Emphasizing the need to facilitate team agility (00:32:35) Highlighting the joys of post-acquisition integration (00:36:09) Drawing lessons from Ludwig Jesselson's principles (00:40:34) Comparing the risks and rewards of early versus late adoption (00:44:09) Reflecting on errors made in trend analysis (00:48:59) Strategies for implementing new technologies in enterprises (00:51:59) The significance of thought experiments in strategic decision-making (00:56:00) Recalling transformative events from his early years (00: 57:22) Outlining what makes a meeting 'electric' (01: 01:53) Sharing experiences with exemplary leadership (01:05:02) Strategies for maximizing team potential (01:07:37) Deciding the right time to step away from a business (01:08:58) Unveiling unexpected challenges in entrepreneurship (01:18:45) Philosophies for leading a fulfilling life (01:21:04) Finishing How To Make A Few Billion Dollars (01:22:53) The kindest thing anyone has ever done for Brad

Global diamond company De Beers spent decades convincing couples that true love required a diamond. But now, lab-grown diamonds that are identical to naturally-mined ones are flooding the market with cheaper options and reshaping the diamond business completely. WSJ’s Jenny Strasburg takes us inside the showdown in the diamond market, and we speak to a ring shopper weighing her options. Jessica Mendoza hosts. Further Listening:-One American Company Taking on China's Rare-Earth Dominance-Can Pepsi Make a Comeback?-How Target Got Off TargetSign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe sits down with Khalil Rountree Jr., a professional mixed martial artist competing in the Light Heavyweight division of the UFC.www.ufc.com/athlete/khalil-rountree-jr This video is sponsored by BetterHelp. Visit https://BetterHelp.com/JRE Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this urgent talk, political scientist Heni Ozi Cukier analyzes the social, economic, political and military conditions that preceded the last two world wars, revealing how historical patterns and today’s geopolitical shifts may be pointing us in a dangerously familiar direction. Connecting past and present, he challenges us to recognize the warning signs — and act before it’s too late. Hosted on Acast. See acast.com/privacy for more information.